Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 31802..32457 Replicon chromosome
Accession NZ_CP048736
Organism Enterobacter sp. T2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag G0034_RS00155 Protein ID WP_228037371.1
Coordinates 31802..32041 (+) Length 80 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G0034_RS00160 Protein ID WP_023331687.1
Coordinates 32038..32457 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G0034_RS00130 (27392) 27392..28480 + 1089 WP_032635252.1 cellulase family glycosylhydrolase -
G0034_RS00135 (28383) 28383..29567 - 1185 WP_179120398.1 multidrug efflux MFS transporter EmrD -
G0034_RS00140 (29743) 29743..30576 - 834 WP_047343396.1 EamA family transporter -
G0034_RS00145 (30639) 30639..31085 - 447 WP_014881927.1 GNAT family N-acetyltransferase -
G0034_RS00155 (31802) 31802..32041 + 240 WP_228037371.1 type II toxin-antitoxin system HigB family toxin Toxin
G0034_RS00160 (32038) 32038..32457 + 420 WP_023331687.1 helix-turn-helix domain-containing protein Antitoxin
G0034_RS00165 (32607) 32607..32705 + 99 WP_023331688.1 ilvB operon leader peptide IvbL -
G0034_RS00170 (32812) 32812..34500 + 1689 WP_179120399.1 acetolactate synthase large subunit -
G0034_RS00175 (34504) 34504..34791 + 288 WP_010426528.1 acetolactate synthase small subunit -
G0034_RS00180 (34874) 34874..35467 + 594 WP_014881931.1 transcriptional regulator UhpA -
G0034_RS00185 (35464) 35464..36969 + 1506 WP_047028137.1 signal transduction histidine-protein kinase/phosphatase UhpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(3-68)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-136)


Sequences

Toxin        


Download         Length: 80 a.a.        Molecular weight: 9484.06 Da        Isoelectric Point: 10.4651

>T149930 WP_228037371.1 NZ_CP048736:31802-32041 [Enterobacter sp. T2]
MGRTIEKSHCPTPVALRKIFPTLDNLKYLDKHYVIDIANNNLRIVALIFFESQKFYVRHVFTNKEYDRFTEKHRTKGKK

Download         Length: 240 bp

>T149930 NZ_CP064351:401112-401378 [Vibrio cholerae C6706]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15561.18 Da        Isoelectric Point: 5.6761

>AT149930 WP_023331687.1 NZ_CP048736:32038-32457 [Enterobacter sp. T2]
MMIVADAMKATHALVAAVPLLGEHPNEKDYQDALELVEYLLMNEPGSPLLDIVCARIRRYEANRPEIVALRQEMESVPVG
IAVLRTLMDQYKLTISDFQDEIGSKSMVSRVLNGQRQLTLNHIKKLAARFGVSPALFIE

Download         Length: 420 bp

>AT149930 NZ_CP064351:401365-401610 [Vibrio cholerae C6706]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References