Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 317861..318374 Replicon chromosome
Accession NZ_CP048732
Organism Mammaliicoccus sciuri strain NWAF26

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag G3T51_RS01605 Protein ID WP_084756269.1
Coordinates 318108..318374 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag G3T51_RS01600 Protein ID WP_084756271.1
Coordinates 317861..318115 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G3T51_RS01585 313628..314866 - 1239 WP_107602246.1 MFS transporter -
G3T51_RS01590 314890..315960 - 1071 WP_075578253.1 alcohol dehydrogenase catalytic domain-containing protein -
G3T51_RS01595 316122..317753 + 1632 WP_075578254.1 ribulokinase -
G3T51_RS01600 317861..318115 + 255 WP_084756271.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
G3T51_RS01605 318108..318374 + 267 WP_084756269.1 Txe/YoeB family addiction module toxin Toxin
G3T51_RS01610 318533..318871 + 339 WP_048540373.1 hypothetical protein -
G3T51_RS01615 318904..319794 - 891 WP_048540374.1 ABC transporter permease subunit -
G3T51_RS01620 319791..320621 - 831 WP_172965088.1 ABC transporter permease subunit -
G3T51_RS01625 320808..321287 - 480 WP_048540376.1 GNAT family N-acetyltransferase -
G3T51_RS01630 321437..321796 - 360 WP_048540377.1 hypothetical protein -
G3T51_RS01635 321844..322410 - 567 WP_172965089.1 histidine phosphatase family protein -
G3T51_RS01640 322648..323339 + 692 Protein_306 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10438.10 Da        Isoelectric Point: 9.6422

>T149926 WP_084756269.1 NZ_CP048732:318108-318374 [Mammaliicoccus sciuri]
MSKRNITFTPSAFEDYEYWLAQDKKLLKKINSLIKSIQRDGLLEGEGKPEPLKGNLQGYCSRRINHEHRLVYMVKENHII
IIGCRYHY

Download         Length: 267 bp

>T149926 NZ_CP064346:25808-26065 [Enterococcus faecium]
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAGTTAATAAAAGATATCGATCGTTCCCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAATGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9433.33 Da        Isoelectric Point: 4.1064

>AT149926 WP_084756271.1 NZ_CP048732:317861-318115 [Mammaliicoccus sciuri]
MTVISYSNARKNFRKLIDKVNNDSDTVTITTNESNAVLMGEDDYNSIMETLYLQQSPANAKHLAKSIEEAEGNNTVEVDI
ESYE

Download         Length: 255 bp

>AT149926 NZ_CP064346:25546-25815 [Enterococcus faecium]
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTACGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References