Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3405783..3406429 Replicon chromosome
Accession NZ_CP048692
Organism Proteus mirabilis strain HNS2p

Toxin (Protein)


Gene name higB Uniprot ID A0A8E4FP08
Locus tag G3T55_RS15770 Protein ID WP_060555121.1
Coordinates 3405783..3406130 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8E4FP64
Locus tag G3T55_RS15775 Protein ID WP_060555120.1
Coordinates 3406130..3406429 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G3T55_RS15735 (G3T55_15760) 3400887..3401180 - 294 WP_049218683.1 YqjK-like family protein -
G3T55_RS15740 (G3T55_15765) 3401293..3401538 - 246 WP_226894360.1 hypothetical protein -
G3T55_RS15745 (G3T55_15770) 3401858..3403057 - 1200 WP_049218680.1 lipoprotein-releasing ABC transporter permease subunit LolC -
G3T55_RS15750 (G3T55_15775) 3403359..3403760 + 402 WP_049218678.1 g-type lysoyme inhibitor PliG -
G3T55_RS15755 (G3T55_15780) 3404177..3404578 - 402 WP_060555124.1 phage holin family protein -
G3T55_RS15760 (G3T55_15785) 3404660..3405013 - 354 WP_060555123.1 hypothetical protein -
G3T55_RS15765 (G3T55_15790) 3405085..3405333 - 249 WP_060555122.1 DUF883 family protein -
G3T55_RS15770 (G3T55_15795) 3405783..3406130 + 348 WP_060555121.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G3T55_RS15775 (G3T55_15800) 3406130..3406429 + 300 WP_060555120.1 XRE family transcriptional regulator Antitoxin
G3T55_RS19710 3406448..3406552 + 105 Protein_3069 transcriptional regulator -
G3T55_RS15780 (G3T55_15805) 3406550..3406738 + 189 WP_060555126.1 DUF5397 family protein -
G3T55_RS15785 (G3T55_15810) 3406742..3407020 + 279 WP_060555119.1 virulence factor -
G3T55_RS15790 (G3T55_15815) 3407487..3408977 + 1491 WP_060555118.1 YadA-like family protein -
G3T55_RS15795 (G3T55_15820) 3409164..3409238 - 75 Protein_3073 IS200/IS605 family transposase -
G3T55_RS15800 (G3T55_15825) 3409232..3409339 - 108 Protein_3074 transposase -
G3T55_RS15805 (G3T55_15830) 3409389..3409595 - 207 WP_060555117.1 plasmid partition protein ParG -
G3T55_RS15810 (G3T55_15835) 3409592..3410215 - 624 WP_060555116.1 ParA family protein -
G3T55_RS15815 (G3T55_15840) 3410684..3411202 - 519 WP_060555115.1 ClbS/DfsB family four-helix bundle protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(J) / blaCMY-2 - 3263596..3450396 186800


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13561.55 Da        Isoelectric Point: 8.8337

>T149889 WP_060555121.1 NZ_CP048692:3405783-3406130 [Proteus mirabilis]
MWAVLFSQRFDDWLNEQEDALQEKVLADLKKLQVYGPELPRLYADTVKGSRYKNMKELRVQFSGRPIRAFYAFDPIRRAI
VLCAGDKSNDKRFYEKLVRIAEDEFTAHLNTLESK

Download         Length: 348 bp

>T149889 NZ_CP064328:c2509497-2509198 [Xylella fastidiosa subsp. fastidiosa]
ATGACCTACACGCTAAAACGACTTGAAGGGTTCTCTGACTGGCTAAAGGGCCTAAAGGATGGGCTGGCAAGGCAGCGCCT
CATCAAGCGCTTACGCAAGGTGCAGCTCGGCAACTTTGGAGACGTGCAGCCGGTGGGTGAAGGCGTGTTTGAAATGCGCG
AACACTTCGGACCTGGCTGGCGTATGTACTACGTGCAGCGAGGCAGCTTTCTCATCGTGATGCTCGGCGGCGGCGACAAG
TCAACGCAGCAATCAGACATTCGTCGGGCCATTGAGCTAGCAAAATCTTTAGAGGATTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11142.01 Da        Isoelectric Point: 5.8962

>AT149889 WP_060555120.1 NZ_CP048692:3406130-3406429 [Proteus mirabilis]
MRTLDEVIASRSPESQTRIKEMADEMILEVGLQMMREELQLSQKQVAEAMGISQPAVTKLEQRGNELKLATLKRYIEAMG
GKLSLDVELPTGKRVAFHL

Download         Length: 300 bp

>AT149889 NZ_CP064328:c2509194-2508886 [Xylella fastidiosa subsp. fastidiosa]
GTGACCATCACAAAGAAAATCAATGTCTCCGAACTGCCAGAGTTCGATGCCGCCGAATACCTGAACAGCGAAGAGGAGGT
AGCCGCGTATCTCACGGCTGTTCTTGAAGAAAACGATCCAGCACTGTTAGCGGCTGCGCTTGGTGACATTGCCCGTTCAC
GTGGTATGTCTCAGATTGCGAAGGATTCTGGCATCACGCGGGAAGCTCTATACAAGGCCCTTCGGCCTGGTAGTGAACCA
CGCTTCGATACGATAAGCCGCGTCTGTACCGCCCTAGGTATACGTCTAGTAGCGCAACCAATGCATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References