Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 68028..68679 Replicon plasmid pYH12138-2
Accession NZ_CP048672
Organism Acinetobacter sp. YH12138 strain YH12138_T

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag G0029_RS17500 Protein ID WP_115736331.1
Coordinates 68028..68384 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G0029_RS17505 Protein ID WP_005237493.1
Coordinates 68377..68679 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G0029_RS17485 63902..65416 + 1515 WP_032073148.1 MFS transporter -
G0029_RS17490 65520..66626 - 1107 WP_032073131.1 two-component sensor histidine kinase AdeS -
G0029_RS17495 66616..67344 - 729 WP_032073130.1 efflux system response regulator transcription factor AdeR -
G0029_RS17500 68028..68384 + 357 WP_115736331.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G0029_RS17505 68377..68679 + 303 WP_005237493.1 helix-turn-helix transcriptional regulator Antitoxin
G0029_RS17510 68721..68882 - 162 Protein_63 IS6 family transposase -
G0029_RS17515 68976..69368 - 393 WP_000550240.1 Cd(II)/Pb(II)-responsive transcriptional regulator -
G0029_RS17520 69458..70738 + 1281 WP_005237495.1 cation transporter -
G0029_RS17525 70802..71506 + 705 WP_180114875.1 IS6 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid aph(3'')-Ib / aph(6)-Id / tet(Y) / aph(3')-Ia / sul2 - 1..105038 105038


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-81)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13600.60 Da        Isoelectric Point: 7.1651

>T149877 WP_115736331.1 NZ_CP048672:68028-68384 [Acinetobacter sp. YH12138]
MWTVITTDLFNQWLEQQDEPTQEKVLAALVVLQQQGPSLGRPLVDTVYESKFTNMKELRVQHRGRSLRAFFAFDPLRQAI
VLCIADKGGKKRFYKDMLDIADEQYQLHLTTLGDKSNG

Download         Length: 357 bp

>T149877 NZ_CP064326:1648628-1648915 [Xylella fastidiosa subsp. multiplex]
ATGGCTAAGTCCTATCGACTGACACCGCTGGCCGAGGCCGATCTTGAAGAAATCTGGTTCTACACATTCAGGCACTGGTC
GATAGAGCAGGCCGACAGCTACCACCGCAGCCTAGTTGCAGTTTTCGAGGGGCTGGCAGCAGGTACAAAGCAAGGCTGCC
CTTCTGTTTTGCCGGACTTCAATAAATACCTATGTGGTTCGCATGTAGTGTATTTCATGGATTACGCCGATCACTTGGAT
ATTATCCGCATCCTGCATCAGCGGCAGGATACCGAGCGGTACCTATAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11208.99 Da        Isoelectric Point: 6.4759

>AT149877 WP_005237493.1 NZ_CP048672:68377-68679 [Acinetobacter sp. YH12138]
MAKTLQELLASRSPESQARIQKMADELLLENQLHLIREELEISQKELAETLGIKQPSLSAIENRGNDLKISTLKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp

>AT149877 NZ_CP064326:1648393-1648635 [Xylella fastidiosa subsp. multiplex]
ATGAGTCGAAACACATCCGTTGCCCTCGGGCCGCACTTCACCAGCTTTATTGATGCCCAAGTCCAGGGCGGTCGCTACGG
TACCGCCAGCGATGTTGTCAGGGCCGGTCTGCGGCTACTTGAGGAACACGAAACAAAGGTGAAGGCACTGCAAGATGCGC
TGAATGTTGGCCACCAATCCGGCGAGCCGCGCCCGTTCGACAGCGAGGTGTTTTTGAGCCGGATGCACACGCAGCATGGC
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References