Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 30498..31083 Replicon plasmid pYH12138-1
Accession NZ_CP048671
Organism Acinetobacter sp. YH12138 strain YH12138_T

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag G0029_RS16300 Protein ID WP_180109894.1
Coordinates 30763..31083 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G0029_RS16295 Protein ID WP_000369781.1
Coordinates 30498..30770 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G0029_RS16270 25719..26930 + 1212 WP_180110283.1 tryptophan synthase subunit beta -
G0029_RS16275 26927..27712 + 786 WP_180110284.1 tryptophan synthase subunit alpha -
G0029_RS16280 27867..28720 + 854 Protein_31 transposase -
G0029_RS16285 28733..29967 + 1235 Protein_32 IS3 family transposase -
G0029_RS16290 30146..30403 + 258 WP_180109893.1 hypothetical protein -
G0029_RS16295 30498..30770 - 273 WP_000369781.1 helix-turn-helix domain-containing protein Antitoxin
G0029_RS16300 30763..31083 - 321 WP_180109894.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G0029_RS16305 31250..31510 + 261 WP_180109895.1 hypothetical protein -
G0029_RS16310 31649..31963 + 315 WP_180109896.1 hypothetical protein -
G0029_RS16315 32442..33767 - 1326 WP_180109897.1 ISNCY family transposase -
G0029_RS16320 34101..34604 - 504 WP_180109898.1 hypothetical protein -
G0029_RS16325 34605..35351 - 747 WP_180109899.1 hypothetical protein -
G0029_RS16330 35342..35766 - 425 Protein_41 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..207449 207449
- inside IScluster/Tn - - 28733..39542 10809


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12207.94 Da        Isoelectric Point: 5.8723

>T149873 WP_180109894.1 NZ_CP048671:c31083-30763 [Acinetobacter sp. YH12138]
MLFIETSIFTKQIKDLVSDEEYRQLQQDLLVQPDRGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDEETAILRQLVKEQFHG

Download         Length: 321 bp

>T149873 NZ_CP064326:c1042568-1042083 [Xylella fastidiosa subsp. multiplex]
GTGAATATGCAGATTTCGACACCTCATTCACTCACGGCAGCGCATCGACTTGATGAATTCAATTGCGGTGAGCCATCGCT
GGATGATTGGCTTAAACGACGCGCACTGACCAACCATTTAAACGGGGCCAGCCGGACCTTCGTGGTTATCGATGCCAACC
AATACGTGCTTGGGTACTACGCTTTGGCAGCCGGGGCTGTAGCGCATCAAGAGGCCACCCGTGCTATCCGACGTAACATG
CCTGATCCAGTGCCGGTCATGGTGCTCGGAAGGCTGGCTGTGGATACTCGTGCTCAAGGCATCAAACTCGGTGCGGCCTT
GCTTAAAGATACGGTAACTCGTGTGCAGTCCATTGCAGAGAACGCCGGCGTCAGGGCATTGGTAGTCCATGCGTTGAACG
AGCGCGCAAAGCAATTCTACGAGTACTATGGTTTTCGAGCGTCACCAATGCACCTGATGACCTTGATGCTTCCGATTAAA
TTCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10149.61 Da        Isoelectric Point: 8.6582

>AT149873 WP_000369781.1 NZ_CP048671:c30770-30498 [Acinetobacter sp. YH12138]
MDNNLFDDLVASIKEAGAIKRKEVKASRVTELELPDIKEVREKTGLSQNEFAARLHISPRTLQNWEQGRRYPTGPAATLI
RILDAHPSLI

Download         Length: 273 bp

>AT149873 NZ_CP064326:c1042837-1042565 [Xylella fastidiosa subsp. multiplex]
ATGCGCGACGCTTCCATCAACTTACGTGCCATGCCTGAGCAGCGCGACTTGATTGACCAGGCTGCTAATCTATTAGGCAA
GAATCGCTCAGACTTCATGCTAGAAGCTGCGTGCGAGCGTGCGAAAGCAATTATCCTGGATCAAGTCTTTTTCAATCTGG
ACGAAGAGAGGTTCCGGCAATTCACTGTGTTGCTTAATGCGCCACAAGACACCAATCCAGGCCTTAATCGCCTGATGGCA
ATTAAGGCTCCGTGGAGCATCAGCAATACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References