Detailed information of TA system TA149832

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4121979..4122237
• Replicon: chromosome
• Accession: NZ_CP048647
• Organism: Escherichia coli strain GW-AmxH19

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: G3273_RS19710
• Protein ID: WP_000809168.1
• Coordinates: 4122085..4122237 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4121979..4122036 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G3273_RS19695	4117808..4119067	-	1260	WP_000494928.1	hypothetical protein	-
G3273_RS19700	4119196..4120689	-	1494	WP_001468392.1	sulfatase-like hydrolase/transferase	-
G3273_RS19705	4120709..4121470	-	762	WP_001274832.1	hypothetical protein	-
-	4121979..4122036	-	58	-	-	Antitoxin
G3273_RS19710	4122085..4122237	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
G3273_RS19715	4122342..4123472	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
G3273_RS19720	4123561..4125477	-	1917	WP_000516135.1	molecular chaperone DnaK	-
G3273_RS19725	4125850..4126254	+	405	WP_000843687.1	DUF2541 family protein	-
G3273_RS19730	4126280..4126993	+	714	WP_001102393.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T149832 WP_000809168.1 NZ_CP048647:4122085-4122237 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T149832 NZ_CP064258:c5378119-5377736 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT149832 NZ_CP048647:c4122036-4121979 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin