149828

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2511765..2512327 Replicon chromosome
Accession NZ_CP048647
Organism Escherichia coli strain GW-AmxH19

Toxin (Protein)


Gene name higB Uniprot ID S1Q1V8
Locus tag G3273_RS11885 Protein ID WP_000605675.1
Coordinates 2511765..2512043 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag G3273_RS11890 Protein ID WP_000781370.1
Coordinates 2512043..2512327 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G3273_RS11860 2507353..2507784 - 432 WP_000152305.1 peroxiredoxin OsmC -
G3273_RS11865 2508129..2508344 + 216 WP_000495766.1 biofilm-dependent modulation protein -
G3273_RS11870 2508446..2508583 + 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
G3273_RS11875 2508739..2510436 + 1698 WP_000433462.1 malate dehydrogenase -
G3273_RS11880 2510569..2511579 + 1011 WP_000642412.1 alcohol dehydrogenase AdhP -
G3273_RS11885 2511765..2512043 + 279 WP_000605675.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G3273_RS11890 2512043..2512327 + 285 WP_000781370.1 HigA family addiction module antidote protein Antitoxin
G3273_RS11895 2512556..2513209 - 654 WP_000045647.1 formate dehydrogenase-N subunit gamma -
G3273_RS11900 2513202..2514086 - 885 WP_001240584.1 formate dehydrogenase N subunit beta -
G3273_RS11905 2514099..2517146 - 3048 WP_077634457.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10537.16 Da        Isoelectric Point: 7.3206

>T149828 WP_000605675.1 NZ_CP048647:2511765-2512043 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T149828 NZ_CP064258:4190362-4190580 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT149828 WP_000781370.1 NZ_CP048647:2512043-2512327 [Escherichia coli]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT149828 NZ_CP064258:4189961-4190335 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1Q1V8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CUG6

References