Detailed information of TA system TA149808

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 2283244..2283551
• Replicon: chromosome
• Accession: NZ_CP048643
• Organism: Staphylococcus aureus strain SR153

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U0AGH1
• Locus tag: GAU34_RS11300
• Protein ID: WP_072482930.1
• Coordinates: 2283375..2283551 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2283244..2283383 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GAU34_RS11260	2278809..2278988	+	180	WP_000669789.1	hypothetical protein	-
GAU34_RS11265	2279299..2279559	+	261	WP_001791826.1	hypothetical protein	-
GAU34_RS11270	2279612..2279962	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
GAU34_RS11275	2280472..2280807	-	336	Protein_2187	SH3 domain-containing protein	-
GAU34_RS11280	2281460..2281951	-	492	WP_000920041.1	staphylokinase	-
GAU34_RS11285	2282142..2282897	-	756	WP_000861038.1	CHAP domain-containing protein	-
GAU34_RS11290	2282909..2283163	-	255	WP_000611512.1	phage holin	-
GAU34_RS11295	2283215..2283322	+	108	Protein_2191	hypothetical protein	-
-	2283244..2283383	+	140	NuclAT_0	-	Antitoxin
-	2283244..2283383	+	140	NuclAT_0	-	Antitoxin
-	2283244..2283383	+	140	NuclAT_0	-	Antitoxin
-	2283244..2283383	+	140	NuclAT_0	-	Antitoxin
GAU34_RS11300	2283375..2283551	-	177	WP_072482930.1	putative holin-like toxin	Toxin
GAU34_RS11305	2283659..2284432	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
GAU34_RS11310	2284805..2285179	-	375	WP_000340977.1	hypothetical protein	-
GAU34_RS11315	2285235..2285522	-	288	WP_001262621.1	hypothetical protein	-
GAU34_RS11320	2285568..2285720	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / sea / hlb / sell / sec / tsst-1	2279612..2347305	67693

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6883.46 Da
• Isoelectric Point: 10.6777

>T149808 WP_072482930.1 NZ_CP048643:c2283551-2283375 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIAFIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T149808 NZ_CP064252:878608-879015 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT149808 NZ_CP048643:2283244-2283383 [Staphylococcus aureus]
ATATATATAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• AlphaFold DB: A0A4U0AGH1

Antitoxin