Detailed information of TA system TA149805

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 2129682..2129862
• Replicon: chromosome
• Accession: NZ_CP048643
• Organism: Staphylococcus aureus strain SR153

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: GAU34_RS10325
• Protein ID: WP_001801861.1
• Coordinates: 2129682..2129777 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2129805..2129862 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GAU34_RS10295	2124846..2125496	+	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-
GAU34_RS10300	2125577..2126284	+	708	WP_176439004.1	DUF4352 domain-containing protein	-
GAU34_RS14780	2126316..2126504	-	189	WP_001628009.1	hypothetical protein	-
GAU34_RS10305	2126646..2127272	+	627	WP_000669024.1	hypothetical protein	-
GAU34_RS10310	2127313..2127654	+	342	WP_000627540.1	DUF3969 family protein	-
GAU34_RS10315	2127755..2128327	+	573	WP_000414216.1	hypothetical protein	-
GAU34_RS10320	2128525..2129537	-	1013	Protein_2034	IS3 family transposase	-
GAU34_RS10325	2129682..2129777	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	2129805..2129862	-	58	-	-	Antitoxin
GAU34_RS10330	2129900..2130001	+	102	WP_001792025.1	hypothetical protein	-
GAU34_RS10335	2129979..2130140	-	162	Protein_2037	transposase	-
GAU34_RS10340	2130131..2130625	-	495	Protein_2038	transposase	-
GAU34_RS10345	2131077..2132306	-	1230	WP_000072627.1	restriction endonuclease subunit S	-
GAU34_RS10350	2132299..2133855	-	1557	WP_000028669.1	type I restriction-modification system subunit M	-
GAU34_RS10355	2134019..2134153	-	135	WP_001791797.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T149805 WP_001801861.1 NZ_CP048643:2129682-2129777 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T149805 NZ_CP064252:330149-330517 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT149805 NZ_CP048643:c2129862-2129805 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin