Detailed information of TA system TA149798

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 983541..983819
• Replicon: chromosome
• Accession: NZ_CP048643
• Organism: Staphylococcus aureus strain SR153

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: GAU34_RS04765
• Protein ID: WP_001802298.1
• Coordinates: 983541..983645 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	983641..983819 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GAU34_RS04745	980338..981120	+	783	WP_000908182.1	ABC transporter ATP-binding protein	-
GAU34_RS04750	981188..982045	+	858	WP_000370925.1	Cof-type HAD-IIB family hydrolase	-
GAU34_RS04755	982703..982861	-	159	WP_001792784.1	hypothetical protein	-
GAU34_RS04765	983541..983645	+	105	WP_001802298.1	hypothetical protein	Toxin
-	983641..983819	-	179	-	-	Antitoxin
GAU34_RS04770	984078..985169	-	1092	WP_000495669.1	hypothetical protein	-
GAU34_RS04775	985435..986412	-	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
GAU34_RS04780	986414..986734	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
GAU34_RS04785	986886..987551	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T149798 WP_001802298.1 NZ_CP048643:983541-983645 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T149798 NZ_CP064246:c5406094-5405711 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT149798 NZ_CP048643:c983819-983641 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin