Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 725530..726047 Replicon chromosome
Accession NZ_CP048643
Organism Staphylococcus aureus strain SR153

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag GAU34_RS03425 Protein ID WP_164094422.1
Coordinates 725781..726047 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag GAU34_RS03420 Protein ID WP_000584499.1
Coordinates 725530..725781 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GAU34_RS03390 721228..721947 + 720 WP_000479576.1 amino acid ABC transporter permease -
GAU34_RS03395 721944..722675 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
GAU34_RS03400 722772..724022 - 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
GAU34_RS03405 724277..724639 + 363 WP_000819843.1 DUF4467 domain-containing protein -
GAU34_RS03410 724658..725257 + 600 WP_000162810.1 DsbA family protein -
GAU34_RS03415 725264..725365 + 102 Protein_679 hypothetical protein -
GAU34_RS03420 725530..725781 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GAU34_RS03425 725781..726047 + 267 WP_164094422.1 Txe/YoeB family addiction module toxin Toxin
GAU34_RS03430 726082..726153 + 72 Protein_682 hypothetical protein -
GAU34_RS03435 726342..727889 + 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
GAU34_RS03440 728075..728542 + 468 WP_000153347.1 SRPBCC domain-containing protein -
GAU34_RS03445 728626..728808 + 183 WP_000230292.1 hypothetical protein -
GAU34_RS03450 729025..729849 + 825 WP_000572038.1 formate/nitrite transporter family protein -
GAU34_RS03455 730083..730619 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10406.94 Da        Isoelectric Point: 10.0573

>T149796 WP_164094422.1 NZ_CP048643:725781-726047 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLAGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T149796 NZ_CP064246:c4921368-4921084 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT149796 WP_000584499.1 NZ_CP048643:725530-725781 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT149796 NZ_CP064246:c4921600-4921358 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References