Detailed information of TA system TA149794

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 700368..700552
• Replicon: chromosome
• Accession: NZ_CP048643
• Organism: Staphylococcus aureus strain SR153

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: GAU34_RS03290
• Protein ID: WP_000482652.1
• Coordinates: 700368..700475 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	700492..700552 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GAU34_RS03265	695730..696203	+	474	WP_000456486.1	GyrI-like domain-containing protein	-
GAU34_RS03270	696326..697537	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
GAU34_RS03275	697719..698378	-	660	WP_000831298.1	membrane protein	-
GAU34_RS03280	698438..699580	-	1143	WP_164094421.1	glycerate kinase	-
GAU34_RS03285	699848..700234	+	387	WP_000779360.1	flippase GtxA	-
GAU34_RS03290	700368..700475	+	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	700492..700552	-	61	-	-	Antitoxin
GAU34_RS03295	701178..702941	+	1764	WP_001064825.1	ABC transporter ATP-binding protein/permease	-
GAU34_RS03300	702966..704699	+	1734	WP_063653200.1	ABC transporter ATP-binding protein/permease	-
GAU34_RS03305	704930..705097	+	168	Protein_657	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T149794 WP_000482652.1 NZ_CP048643:700368-700475 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T149794 NZ_CP064246:4203208-4203426 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT149794 NZ_CP048643:c700552-700492 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin