Detailed information of TA system TA149790

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 11643..12222
• Replicon: chromosome
• Accession: NZ_CP048643
• Organism: Staphylococcus aureus strain SR153

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: GAU34_RS00130
• Protein ID: WP_001025401.1
• Coordinates: 11977..12222 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	11643..12008 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GAU34_RS00080	7923..8480	-	558	WP_000645042.1	DUF2815 family protein	-
GAU34_RS00085	8506..9672	-	1167	WP_000762547.1	DUF2800 domain-containing protein	-
GAU34_RS00090	9669..10031	-	363	WP_000985976.1	hypothetical protein	-
GAU34_RS00095	10046..10369	-	324	WP_000174994.1	hypothetical protein	-
GAU34_RS00100	10448..10609	-	162	WP_001285963.1	DUF1270 family protein	-
GAU34_RS00105	10622..10885	-	264	WP_001124159.1	helix-turn-helix domain-containing protein	-
GAU34_RS00110	10940..11149	+	210	WP_000642492.1	hypothetical protein	-
GAU34_RS00115	11139..11282	-	144	WP_000939498.1	hypothetical protein	-
GAU34_RS00120	11373..11588	-	216	WP_001097552.1	hypothetical protein	-
GAU34_RS00125	11643..12008	+	366	WP_001128433.1	hypothetical protein	Antitoxin
GAU34_RS00130	11977..12222	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
GAU34_RS00135	12272..12490	-	219	WP_001001383.1	hypothetical protein	-
GAU34_RS00140	12506..13282	-	777	WP_061389040.1	phage antirepressor	-
GAU34_RS00145	13298..13515	-	218	Protein_30	helix-turn-helix transcriptional regulator	-
GAU34_RS00150	13657..14379	+	723	WP_024936995.1	XRE family transcriptional regulator	-
GAU34_RS14740	14391..14537	+	147	WP_001049401.1	hypothetical protein	-
GAU34_RS00155	14534..14719	+	186	WP_024936996.1	hypothetical protein	-
GAU34_RS00160	14775..15359	+	585	WP_161081411.1	hypothetical protein	-
GAU34_RS00165	15589..15735	+	147	WP_078367450.1	hypothetical protein	-
GAU34_RS00170	15732..16346	-	615	WP_031808062.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1774..17661	15887

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T149790 WP_001025401.1 NZ_CP048643:c12222-11977 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T149790 NZ_CP064246:744965-745450 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Nucleotide

• Length: 366 bp

>AT149790 NZ_CP048643:11643-12008 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTGGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin