Detailed information of TA system TA149771

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prlF-yhaV (relBE)/YhaV-PrlF
• Location: 1238573..1239426
• Replicon: chromosome
• Accession: NZ_CP048618
• Organism: Legionella pneumophila strain ERS1305867

Toxin (Protein)

• Gene name: yhaV
• Uniprot ID: -
• Locus tag: GCO85_RS05645
• Protein ID: WP_061636270.1
• Coordinates: 1238573..1239079 (-)
• Length: 169 a.a.

Antitoxin (Protein)

• Gene name: prlF
• Uniprot ID: -
• Locus tag: GCO85_RS05650
• Protein ID: WP_061636269.1
• Coordinates: 1239079..1239426 (-)
• Length: 116 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GCO85_RS05620	1234931..1235185	+	255	WP_058478972.1	type II toxin-antitoxin system HicA family toxin	-
GCO85_RS05625	1235182..1235604	+	423	WP_065235631.1	type II toxin-antitoxin system HicB family antitoxin	-
GCO85_RS05630	1235843..1236796	-	954	WP_061636272.1	hypothetical protein	-
GCO85_RS05635	1236800..1237444	-	645	WP_058478970.1	hypothetical protein	-
GCO85_RS05640	1237859..1238227	+	369	WP_061636271.1	MarR family transcriptional regulator	-
GCO85_RS05645	1238573..1239079	-	507	WP_061636270.1	type II toxin-antitoxin system YhaV family toxin	Toxin
GCO85_RS05650	1239079..1239426	-	348	WP_061636269.1	type II toxin-antitoxin system PrlF family antitoxin	Antitoxin
GCO85_RS05655	1239496..1240746	-	1251	WP_061636268.1	tyrosine-type recombinase/integrase	-
GCO85_RS05660	1241229..1242095	+	867	WP_027220967.1	hypothetical protein	-
GCO85_RS05665	1242199..1242558	+	360	WP_032832446.1	hypothetical protein	-
GCO85_RS05670	1242603..1242977	-	375	WP_032832431.1	type II toxin-antitoxin system death-on-curing family toxin	-
GCO85_RS05675	1242977..1243213	-	237	WP_027220969.1	hypothetical protein	-
GCO85_RS05680	1243591..1243866	+	276	WP_027220970.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin endonuclease, YhaV (14-150)

Antitoxin

• PrlF antitoxin (8-105)

Sequences

Toxin

Protein

• Length: 169 a.a.
• Molecular weight: 19371.97 Da
• Isoelectric Point: 9.6411

>T149771 WP_061636270.1 NZ_CP048618:c1239079-1238573 [Legionella pneumophila]
MGDNSIITINGWAILCHPLFLQQVEALANEVENAKQKDPSNFHTRSSTKKLAAIAKLAFEKIPNDPAATEFRQGSTLGNN
HKHWFRAKFFQQYRLFFRFHQESKIIIYAWVNDDSSKRAYESKADAYHIFRKMLESGHPPDNWDELLKEANNTSLMKKLT
TSLDALKS

Nucleotide

• Length: 507 bp

>T149771 NZ_CP064241:745313-745798 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Protein

• Length: 116 a.a.
• Molecular weight: 13211.87 Da
• Isoelectric Point: 4.6547

>AT149771 WP_061636269.1 NZ_CP048618:c1239426-1239079 [Legionella pneumophila]
MARLLQTESTLTDRYQTTVPDAVRKALHLGKRDKIRYTVQSDGHVLMTRAEEEEDPVITEFLNFIAKDIQNNPKNLTAIS
QDLITRIHSLIANVEVNLDEPLPEDEELTENRVTR

Nucleotide

• Length: 348 bp

>AT149771 NZ_CP064241:745023-745316 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA