Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 42047..42311 | Replicon | plasmid unnamed3 |
| Accession | NZ_CP048612 | ||
| Organism | Escherichia coli strain STEFF_1 | ||
Toxin (Protein)
| Gene name | pndA | Uniprot ID | U9Y6M3 |
| Locus tag | G3M66_RS25505 | Protein ID | WP_001331364.1 |
| Coordinates | 42159..42311 (+) | Length | 51 a.a. |
Antitoxin (RNA)
| Gene name | pndB | ||
| Locus tag | - | ||
| Coordinates | 42047..42109 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G3M66_RS25490 (37286) | 37286..39577 | - | 2292 | WP_001289276.1 | F-type conjugative transfer protein TrbC | - |
| G3M66_RS25495 (39570) | 39570..40640 | - | 1071 | WP_000151582.1 | IncI1-type conjugal transfer protein TrbB | - |
| G3M66_RS25500 (40659) | 40659..41867 | - | 1209 | WP_000121273.1 | IncI1-type conjugal transfer protein TrbA | - |
| - (42047) | 42047..42109 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (42047) | 42047..42109 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (42047) | 42047..42109 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (42047) | 42047..42109 | - | 63 | NuclAT_0 | - | Antitoxin |
| G3M66_RS25505 (42159) | 42159..42311 | + | 153 | WP_001331364.1 | Hok/Gef family protein | Toxin |
| G3M66_RS25510 (42383) | 42383..42634 | - | 252 | WP_001291964.1 | hypothetical protein | - |
| G3M66_RS25850 (43133) | 43133..43228 | + | 96 | WP_001303310.1 | DinQ-like type I toxin DqlB | - |
| G3M66_RS25520 (43293) | 43293..43469 | - | 177 | WP_001054897.1 | hypothetical protein | - |
| G3M66_RS25525 (43861) | 43861..44070 | + | 210 | WP_039025903.1 | HEAT repeat domain-containing protein | - |
| G3M66_RS25530 (44142) | 44142..44804 | - | 663 | WP_000644796.1 | plasmid IncI1-type surface exclusion protein ExcA | - |
| G3M66_RS25535 (44875) | 44875..47043 | - | 2169 | WP_000698354.1 | DotA/TraY family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..88925 | 88925 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5775.13 Da Isoelectric Point: 8.7948
>T149767 WP_001331364.1 NZ_CP048612:42159-42311 [Escherichia coli]
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
Download Length: 153 bp
>T149767 NZ_CP064239:c8041-7727 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA
Antitoxin
Download Length: 63 bp
>AT149767 NZ_CP048612:c42109-42047 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
