Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 788928..789621 Replicon chromosome
Accession NZ_CP048609
Organism Escherichia coli strain STEFF_1

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag G3M66_RS03830 Protein ID WP_000415584.1
Coordinates 788928..789224 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag G3M66_RS03835 Protein ID WP_000650107.1
Coordinates 789226..789621 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G3M66_RS03795 (784016) 784016..784330 - 315 WP_000958598.1 putative quinol monooxygenase -
G3M66_RS03800 (784361) 784361..784942 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
G3M66_RS03805 (785261) 785261..785593 + 333 WP_023149630.1 DUF2645 family protein -
G3M66_RS03810 (785639) 785639..786988 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
G3M66_RS03815 (786985) 786985..787644 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
G3M66_RS03820 (787796) 787796..788188 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
G3M66_RS03825 (788241) 788241..788723 + 483 WP_000183505.1 GyrI-like domain-containing protein -
G3M66_RS03830 (788928) 788928..789224 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
G3M66_RS03835 (789226) 789226..789621 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
G3M66_RS03840 (789754) 789754..791361 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
G3M66_RS03845 (791499) 791499..793757 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T149736 WP_000415584.1 NZ_CP048609:788928-789224 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T149736 NZ_CP064232:797940-798350 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT149736 WP_000650107.1 NZ_CP048609:789226-789621 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT149736 NZ_CP064232:797693-797959 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References