Detailed information of TA system TA149653

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 182956..183178
• Replicon: chromosome
• Accession: NZ_CP048603
• Organism: Escherichia coli strain ChlosBP-23-1

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: G3M71_RS00845
• Protein ID: WP_001295224.1
• Coordinates: 183071..183178 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	182956..183022 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G3M71_RS00825	178397..179299	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
G3M71_RS00830	179310..180293	+	984	WP_001196477.1	dipeptide ABC transporter ATP-binding protein	-
G3M71_RS00835	180290..181294	+	1005	WP_000103570.1	dipeptide ABC transporter ATP-binding subunit DppF	-
G3M71_RS00840	181324..182595	-	1272	WP_014640225.1	amino acid permease	-
-	182956..183022	-	67	-	-	Antitoxin
G3M71_RS00845	183071..183178	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
G3M71_RS00850	183264..184943	-	1680	WP_000191567.1	cellulose biosynthesis protein BcsG	-
G3M71_RS00855	184940..185131	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
G3M71_RS00860	185128..186699	-	1572	WP_105494795.1	cellulose biosynthesis protein BcsE	-
G3M71_RS00865	186972..187160	+	189	WP_163388347.1	hypothetical protein	-
G3M71_RS00870	187172..187924	+	753	WP_000279546.1	cellulose biosynthesis protein BcsQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T149653 WP_001295224.1 NZ_CP048603:183071-183178 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T149653 NZ_CP064208:c4793339-4793055 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT149653 NZ_CP048603:c183022-182956 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin