Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4690334..4691023 Replicon chromosome
Accession NZ_CP048598
Organism Klebsiella aerogenes strain AUH-KAM-9

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag F8267_RS22140 Protein ID WP_042894575.1
Coordinates 4690334..4690630 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag F8267_RS22145 Protein ID WP_032711784.1
Coordinates 4690688..4691023 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F8267_RS22130 4688373..4689518 + 1146 WP_032714650.1 porin OmpC -
F8267_RS22135 4689663..4690097 + 435 WP_015366316.1 universal stress protein UspF -
F8267_RS22140 4690334..4690630 + 297 WP_042894575.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F8267_RS22145 4690688..4691023 + 336 WP_032711784.1 HigA family addiction module antidote protein Antitoxin
F8267_RS22150 4691062..4691328 + 267 Protein_4299 tyrosine-type recombinase/integrase -
F8267_RS22155 4691376..4692311 + 936 WP_032711785.1 tRNA 2-thiocytidine(32) synthetase TtcA -
F8267_RS22160 4692359..4693732 - 1374 WP_048231211.1 ATP-dependent RNA helicase DbpA -
F8267_RS22165 4694217..4695200 - 984 WP_015366313.1 zinc transporter ZntB -
F8267_RS22170 4695381..4695824 + 444 WP_020078629.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(7-96)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-84)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11554.16 Da        Isoelectric Point: 7.4629

>T149641 WP_042894575.1 NZ_CP048598:4690334-4690630 [Klebsiella aerogenes]
MQNHIGSFRDVWLEEFFLHSAPHKKIPPDIHTTLARKLDIINAAVTYLDLRSPPGNRYEELNGKLEGYSSIRINQQYRLI
FKWVDGKAEDLYLDPHKY

Download         Length: 297 bp

>T149641 NZ_CP064205:c4922978-4922694 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12694.53 Da        Isoelectric Point: 7.2045

>AT149641 WP_032711784.1 NZ_CP048598:4690688-4691023 [Klebsiella aerogenes]
MKQATRKPTTVGDILQFEYLEPLDLKINELAEMIHVHRNSVSALVNNNRKLTTDMAFRLSKAFNTTVDFWLNLQAAVDLW
EVENDTRAQEEFSRIVPASKFIASKADKKVA

Download         Length: 336 bp

>AT149641 NZ_CP064205:c4923210-4922968 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References