Detailed information of TA system TA149546

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1192064..1192763
• Replicon: chromosome
• Accession: NZ_CP048461
• Organism: Burkholderia multivorans strain P1Bm2009

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: G0D86_RS20640
• Protein ID: WP_059786235.1
• Coordinates: 1192467..1192763 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: B9B077
• Locus tag: G0D86_RS20635
• Protein ID: WP_006397015.1
• Coordinates: 1192064..1192465 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G0D86_RS20615	1187759..1189111	-	1353	WP_105842813.1	LLM class flavin-dependent oxidoreductase	-
G0D86_RS20620	1189108..1190169	-	1062	WP_206381911.1	MsnO8 family LLM class oxidoreductase	-
G0D86_RS20625	1190201..1191142	-	942	WP_206381912.1	transporter substrate-binding domain-containing protein	-
G0D86_RS20630	1191208..1191768	-	561	WP_155825035.1	GNAT family N-acetyltransferase	-
G0D86_RS20635	1192064..1192465	-	402	WP_006397015.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
G0D86_RS20640	1192467..1192763	-	297	WP_059786235.1	type II toxin-antitoxin system MqsR family toxin	Toxin
G0D86_RS20645	1192883..1193917	-	1035	WP_006397017.1	succinylglutamate desuccinylase/aspartoacylase family protein	-
G0D86_RS20650	1194020..1194292	-	273	WP_012216969.1	hypothetical protein	-
G0D86_RS20655	1194500..1196044	-	1545	WP_170935331.1	sensor domain-containing diguanylate cyclase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (72-109)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11215.10 Da
• Isoelectric Point: 9.1122

>T149546 WP_059786235.1 NZ_CP048461:c1192763-1192467 [Burkholderia multivorans]
MEKRTPHCKLPRVKALIEAGKVRLTASAVIGARQMGFTESETIDVVRALTPFEFHKSMTTYADHTIWQDVYRPCTMRGDV
YLKLTVVDDVLIVSFKER

Nucleotide

• Length: 297 bp

>T149546 NZ_CP064128:c1137332-1137129 [Yersinia pestis]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14477.62 Da
• Isoelectric Point: 7.0834

>AT149546 WP_006397015.1 NZ_CP048461:c1192465-1192064 [Burkholderia multivorans]
MKCPACGAAALVRDTRDIPYTYKGESTVIPHVTGEFCPACGESVLDVDEATRFGEAVSAFNRQVNATLVDPKFIATVRKK
LKLDQREAAEIFGGGVNAFSRYETGKTNPPLALVKLLKLLDRHPDLLDEVRAA

Nucleotide

• Length: 402 bp

>AT149546 NZ_CP064128:c1137749-1137381 [Yersinia pestis]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Structures

Antitoxin

• AlphaFold DB: B9B077