Detailed information of TA system TA149506

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1191672..1192371
• Replicon: chromosome
• Accession: NZ_CP048446
• Organism: Burkholderia multivorans strain P1Bm2015

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: G0D91_RS20670
• Protein ID: WP_059786235.1
• Coordinates: 1192075..1192371 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: B9B077
• Locus tag: G0D91_RS20665
• Protein ID: WP_006397015.1
• Coordinates: 1191672..1192073 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G0D91_RS20645	1187367..1188719	-	1353	WP_105842813.1	LLM class flavin-dependent oxidoreductase	-
G0D91_RS20650	1188716..1189777	-	1062	WP_206381911.1	MsnO8 family LLM class oxidoreductase	-
G0D91_RS20655	1189809..1190750	-	942	WP_206381912.1	transporter substrate-binding domain-containing protein	-
G0D91_RS20660	1190816..1191376	-	561	WP_155825035.1	GNAT family N-acetyltransferase	-
G0D91_RS20665	1191672..1192073	-	402	WP_006397015.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
G0D91_RS20670	1192075..1192371	-	297	WP_059786235.1	type II toxin-antitoxin system MqsR family toxin	Toxin
G0D91_RS20675	1192491..1193525	-	1035	WP_006397017.1	succinylglutamate desuccinylase/aspartoacylase family protein	-
G0D91_RS20680	1193628..1193900	-	273	WP_012216969.1	hypothetical protein	-
G0D91_RS20685	1194108..1195652	-	1545	WP_170935331.1	sensor domain-containing diguanylate cyclase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (72-109)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11215.10 Da
• Isoelectric Point: 9.1122

>T149506 WP_059786235.1 NZ_CP048446:c1192371-1192075 [Burkholderia multivorans]
MEKRTPHCKLPRVKALIEAGKVRLTASAVIGARQMGFTESETIDVVRALTPFEFHKSMTTYADHTIWQDVYRPCTMRGDV
YLKLTVVDDVLIVSFKER

Nucleotide

• Length: 297 bp

>T149506 NZ_CP064121:2193471-2193653 [Yersinia pestis]
GTGAAAAGTTCGGAGCTGATAAAACTGCTCGAAACAAATGGTTGGAAGTTGATGAGAGTTAAAGGCAGTCATCATCAATT
CAAACATCCTGATTTCGCGGCAGTCATAACAGTACCGCATCCCAAAAAGGATGTTAAACCGGGAACCCTCCGGCAAATTC
TGAAAGATGCAAACCTTAGTTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14477.62 Da
• Isoelectric Point: 7.0834

>AT149506 WP_006397015.1 NZ_CP048446:c1192073-1191672 [Burkholderia multivorans]
MKCPACGAAALVRDTRDIPYTYKGESTVIPHVTGEFCPACGESVLDVDEATRFGEAVSAFNRQVNATLVDPKFIATVRKK
LKLDQREAAEIFGGGVNAFSRYETGKTNPPLALVKLLKLLDRHPDLLDEVRAA

Nucleotide

• Length: 402 bp

>AT149506 NZ_CP064121:2193698-2194117 [Yersinia pestis]
ATGGCTATCTATCCCGCCTATGTTCACGTTGATAATGATGGCTCGGCAAGCGGTTATTTCCCCGATGTCAAAGGCTGTAT
TTTTGCCATCAATGCCGGGGAGGATTTATTTGCAGAAGCATCAAGCGCCCTGGATGCACACTTTGAAGCTTTGGTGTCTG
AAGGTATCGAAATTCCTGAAGCTCATGACATGCCTTACCACGTTTACCGTAACCCATGCGATTACGCTGATGGCGGACAG
TGGTATAACGTGAATATTGATATGTCGAAATATGATGGAAAAGTTGAACGAATTAACGTCACTCTTCCGCACCGGCTGAT
TCATCAAATCGATACTATTGTTAAAGTGCGTCCCGAGTATGCCAGCCGAAGCAATTTTCTAGCCGAAGCAGCACGTAAAG
AATTACAGAAATTGGCGTAA

Structures

Antitoxin

• AlphaFold DB: B9B077