Detailed information of TA system TA149497

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1202001..1202700
• Replicon: chromosome
• Accession: NZ_CP048442
• Organism: Burkholderia multivorans strain P2Bm2011a

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: G0D92_RS21050
• Protein ID: WP_059786235.1
• Coordinates: 1202404..1202700 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: B9B077
• Locus tag: G0D92_RS21045
• Protein ID: WP_006397015.1
• Coordinates: 1202001..1202402 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G0D92_RS21025	1197696..1199048	-	1353	WP_105842813.1	LLM class flavin-dependent oxidoreductase	-
G0D92_RS21030	1199045..1200106	-	1062	WP_206381911.1	MsnO8 family LLM class oxidoreductase	-
G0D92_RS21035	1200138..1201079	-	942	WP_206381912.1	transporter substrate-binding domain-containing protein	-
G0D92_RS21040	1201145..1201705	-	561	WP_155825035.1	GNAT family N-acetyltransferase	-
G0D92_RS21045	1202001..1202402	-	402	WP_006397015.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
G0D92_RS21050	1202404..1202700	-	297	WP_059786235.1	type II toxin-antitoxin system MqsR family toxin	Toxin
G0D92_RS21055	1202820..1203854	-	1035	WP_006397017.1	succinylglutamate desuccinylase/aspartoacylase family protein	-
G0D92_RS21060	1203957..1204229	-	273	WP_012216969.1	hypothetical protein	-
G0D92_RS21065	1204437..1205981	-	1545	WP_170935331.1	sensor domain-containing diguanylate cyclase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (72-109)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11215.10 Da
• Isoelectric Point: 9.1122

>T149497 WP_059786235.1 NZ_CP048442:c1202700-1202404 [Burkholderia multivorans]
MEKRTPHCKLPRVKALIEAGKVRLTASAVIGARQMGFTESETIDVVRALTPFEFHKSMTTYADHTIWQDVYRPCTMRGDV
YLKLTVVDDVLIVSFKER

Nucleotide

• Length: 297 bp

>T149497 NZ_CP064119:c3608545-3608342 [Yersinia pestis]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14477.62 Da
• Isoelectric Point: 7.0834

>AT149497 WP_006397015.1 NZ_CP048442:c1202402-1202001 [Burkholderia multivorans]
MKCPACGAAALVRDTRDIPYTYKGESTVIPHVTGEFCPACGESVLDVDEATRFGEAVSAFNRQVNATLVDPKFIATVRKK
LKLDQREAAEIFGGGVNAFSRYETGKTNPPLALVKLLKLLDRHPDLLDEVRAA

Nucleotide

• Length: 402 bp

>AT149497 NZ_CP064119:c3608962-3608594 [Yersinia pestis]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Structures

Antitoxin

• AlphaFold DB: B9B077