Detailed information of TA system TA149453

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 183446..183668
• Replicon: chromosome
• Accession: NZ_CP048439
• Organism: Escherichia coli strain NBRC 3301

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1E8T8
• Locus tag: GXM24_RS00870
• Protein ID: WP_000141634.1
• Coordinates: 183561..183668 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	183446..183512 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GXM24_RS00850	178887..179789	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
GXM24_RS00855	179800..180783	+	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
GXM24_RS00860	180780..181784	+	1005	WP_000107012.1	dipeptide ABC transporter ATP-binding subunit DppF	-
GXM24_RS00865	181814..183085	-	1272	WP_001295225.1	transporter	-
-	183446..183512	-	67	-	-	Antitoxin
GXM24_RS00870	183561..183668	+	108	WP_000141634.1	type I toxin-antitoxin system toxic polypeptide LdrD	Toxin
GXM24_RS00875	183755..185434	-	1680	WP_000191622.1	cellulose biosynthesis protein BcsG	-
GXM24_RS00880	185431..185622	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
GXM24_RS00885	185619..187190	-	1572	WP_001204931.1	cellulose biosynthesis protein BcsE	-
GXM24_RS00890	187463..187651	+	189	WP_001063318.1	YhjR family protein	-
GXM24_RS00895	187663..188415	+	753	Protein_174	cellulose biosynthesis protein BcsQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3916.72 Da
• Isoelectric Point: 9.0157

>T149453 WP_000141634.1 NZ_CP048439:183561-183668 [Escherichia coli]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T149453 NZ_CP064103:c4848881-4848495 [Escherichia coli]
GTGCTTGCCCCAACTGGGCCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGTGTCCCCCACGATCCGTCTTGCGTCTTGAATTCTGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCTGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATATCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT149453 NZ_CP048439:c183512-183446 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• PDB: 5LBJ

Antitoxin