149445

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2321609..2322126 Replicon chromosome
Accession NZ_CP048431
Organism Staphylococcus aureus strain SA1428

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag GZ067_RS11300 Protein ID WP_000113262.1
Coordinates 2321860..2322126 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag GZ067_RS11295 Protein ID WP_000584499.1
Coordinates 2321609..2321860 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZ067_RS11270 2317453..2318772 + 1320 WP_001808146.1 ISL3-like element IS1181 family transposase -
GZ067_RS11275 2318851..2320101 - 1251 WP_001012223.1 FemA/FemB family glycyltransferase FmhA -
GZ067_RS11280 2320356..2320718 + 363 WP_000819843.1 DUF4467 domain-containing protein -
GZ067_RS11285 2320737..2321336 + 600 WP_000162813.1 DsbA family protein -
GZ067_RS11290 2321343..2321444 + 102 WP_031774922.1 hypothetical protein -
GZ067_RS11295 2321609..2321860 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GZ067_RS11300 2321860..2322126 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
GZ067_RS11305 2322422..2323978 + 1557 WP_164026294.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
GZ067_RS11310 2324164..2324631 + 468 WP_000153344.1 SRPBCC domain-containing protein -
GZ067_RS11315 2324718..2324900 + 183 WP_164026296.1 hypothetical protein -
GZ067_RS11320 2325117..2325941 + 825 WP_000572040.1 formate/nitrite transporter family protein -
GZ067_RS11325 2326174..2326710 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2317453..2318772 1319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T149445 WP_000113262.1 NZ_CP048431:2321860-2322126 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T149445 NZ_CP064103:3405563-3405949 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGTAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT149445 WP_000584499.1 NZ_CP048431:2321609-2321860 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT149445 NZ_CP064103:3405939-3406268 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References