Detailed information of TA system TA149443

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2294988..2295172
• Replicon: chromosome
• Accession: NZ_CP048431
• Organism: Staphylococcus aureus strain SA1428

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: GZ067_RS11160
• Protein ID: WP_000482647.1
• Coordinates: 2294988..2295095 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2295112..2295172 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GZ067_RS11135	2290360..2290833	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
GZ067_RS11140	2290956..2292167	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
GZ067_RS11145	2292349..2293008	-	660	WP_164026288.1	hypothetical protein	-
GZ067_RS11150	2293068..2294210	-	1143	WP_001176863.1	glycerate kinase	-
GZ067_RS11155	2294468..2294854	+	387	WP_000779360.1	flippase GtxA	-
GZ067_RS11160	2294988..2295095	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2295112..2295172	-	61	-	-	Antitoxin
GZ067_RS11165	2295799..2297562	+	1764	WP_001064814.1	ABC transporter ATP-binding protein/permease	-
GZ067_RS11170	2297587..2299320	+	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
GZ067_RS11175	2299551..2299718	+	168	WP_001790576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T149443 WP_000482647.1 NZ_CP048431:2294988-2295095 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T149443 NZ_CP064103:2956136-2956243 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT149443 NZ_CP048431:c2295172-2295112 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin