Detailed information of TA system TA149442

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2263187..2263686
• Replicon: chromosome
• Accession: NZ_CP048431
• Organism: Staphylococcus aureus strain SA1428

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: GZ067_RS11020
• Protein ID: WP_000074044.1
• Coordinates: 2263444..2263686 (+)
• Length: 81 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: GZ067_RS11015
• Protein ID: WP_000587618.1
• Coordinates: 2263187..2263444 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GZ067_RS10990	2258260..2259453	+	1194	WP_000675411.1	MFS transporter	-
GZ067_RS10995	2259684..2260433	-	750	WP_000072459.1	hypothetical protein	-
GZ067_RS11000	2260628..2262205	+	1578	WP_000143494.1	FMN-binding glutamate synthase family protein	-
GZ067_RS11005	2262373..2262828	-	456	WP_000732082.1	DUF1307 domain-containing protein	-
GZ067_RS11015	2263187..2263444	+	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GZ067_RS11020	2263444..2263686	+	243	WP_000074044.1	Txe/YoeB family addiction module toxin	Toxin
GZ067_RS11025	2264043..2265119	+	1077	WP_001076672.1	M42 family metallopeptidase	-
GZ067_RS11030	2265367..2266029	+	663	WP_000923523.1	ATP-binding cassette domain-containing protein	-
GZ067_RS11035	2266022..2266798	+	777	WP_000072147.1	iron export ABC transporter permease subunit FetB	-
GZ067_RS11040	2267194..2268381	+	1188	WP_164026282.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-79)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 81 a.a.
• Molecular weight: 9649.18 Da
• Isoelectric Point: 10.1469

>T149442 WP_000074044.1 NZ_CP048431:2263444-2263686 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLILSAWSHYD

Nucleotide

• Length: 243 bp

>T149442 NZ_CP064103:c2765390-2765214 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTGAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT149442 WP_000587618.1 NZ_CP048431:2263187-2263444 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT149442 NZ_CP064103:c2765168-2764752 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACAGTTGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAACAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAATTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CACTGGTGATGGTTTAA

Structures

Antitoxin

• AlphaFold DB: T1YBB2