Detailed information of TA system TA149437

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1011386..1011583
• Replicon: chromosome
• Accession: NZ_CP048431
• Organism: Staphylococcus aureus strain SA1428

Toxin (Protein)

• Gene name: SprG2
• Uniprot ID: -
• Locus tag: GZ067_RS05015
• Protein ID: WP_206208716.1
• Coordinates: 1011476..1011583 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1011386..1011423 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GZ067_RS04975	1006484..1006840	+	357	WP_000766009.1	DoxX family protein	-
GZ067_RS04980	1006929..1007066	-	138	WP_001792054.1	poly(glycerol-phosphate) alpha-glucosyltransferase	-
GZ067_RS04985	1007207..1007497	+	291	WP_001795266.1	hypothetical protein	-
GZ067_RS04990	1007585..1008226	-	642	WP_000571167.1	ABC transporter ATP-binding protein	-
GZ067_RS04995	1008223..1008543	-	321	WP_000668627.1	YxeA family protein	-
GZ067_RS05000	1008546..1010510	-	1965	WP_000870827.1	bacteriocin-associated integral membrane family protein	-
GZ067_RS05005	1010554..1010826	-	273	WP_001797239.1	lactococcin 972 family bacteriocin	-
GZ067_RS05010	1010836..1010937	-	102	WP_031763719.1	hypothetical protein	-
-	1011386..1011423	+	38	-	-	Antitoxin
GZ067_RS05015	1011476..1011583	-	108	WP_206208716.1	putative holin-like toxin	Toxin
GZ067_RS05020	1011853..1012455	-	603	WP_001033865.1	CPBP family intramembrane metalloprotease	-
GZ067_RS05025	1012470..1012646	-	177	WP_000214898.1	YkvS family protein	-
GZ067_RS05030	1012845..1013831	+	987	WP_000668818.1	lipoate--protein ligase	-
GZ067_RS05035	1013912..1014130	-	219	WP_000876826.1	IDEAL domain-containing protein	-
GZ067_RS05040	1014340..1014909	+	570	WP_000287265.1	competence protein ComK	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (3-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3834.78 Da
• Isoelectric Point: 9.5149

>T149437 WP_206208716.1 NZ_CP048431:c1011583-1011476 [Staphylococcus aureus]
VISIANALHLMLSFGMFIVTFICIVVAIINLSNKK

Nucleotide

• Length: 108 bp

>T149437 NZ_CP064103:c859895-859518 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGTACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Nucleotide

• Length: 38 bp

>AT149437 NZ_CP048431:1011386-1011423 [Staphylococcus aureus]
AACATGTCGCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Antitoxin