Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5755479..5756059 Replicon chromosome
Accession NZ_CP048408
Organism Pseudomonas fluorescens strain DR397

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GZH78_RS25830 Protein ID WP_085747693.1
Coordinates 5755479..5755757 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GZH78_RS25835 Protein ID WP_045121630.1
Coordinates 5755772..5756059 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZH78_RS25810 5751061..5751228 - 168 WP_085668053.1 DUF2474 domain-containing protein -
GZH78_RS25815 5751286..5752293 - 1008 WP_039771762.1 cytochrome d ubiquinol oxidase subunit II -
GZH78_RS25820 5752297..5753733 - 1437 WP_039771763.1 cytochrome ubiquinol oxidase subunit I -
GZH78_RS25825 5754134..5755372 + 1239 WP_103385470.1 MFS transporter -
GZH78_RS25830 5755479..5755757 + 279 WP_085747693.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GZH78_RS25835 5755772..5756059 + 288 WP_045121630.1 HigA family addiction module antidote protein Antitoxin
GZH78_RS25840 5756065..5756616 - 552 WP_163976526.1 DJ-1/PfpI family protein -
GZH78_RS25845 5756684..5757133 - 450 WP_163976528.1 YolA family protein -
GZH78_RS25850 5757354..5758649 + 1296 WP_007950999.1 NCS2 family permease -
GZH78_RS25855 5758646..5759725 + 1080 WP_039771766.1 tRNA (uridine(54)-C5)-methyltransferase TrmA -
GZH78_RS25860 5759780..5760226 - 447 WP_039771767.1 hypothetical protein -
GZH78_RS25865 5760223..5760651 - 429 WP_074691513.1 DUF4160 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-75)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10673.22 Da        Isoelectric Point: 8.9401

>T149385 WP_085747693.1 NZ_CP048408:5755479-5755757 [Pseudomonas fluorescens]
MIKSFQHKGLRGFYETGSTRGIRADHAKRLSRMLQFMDRAAAPGDLDLPGWRLHPLKGELCEYWSLSVSGNWRVIFRFAG
SDIELIDYLDYH

Download         Length: 279 bp

>T149385 NZ_CP064055:c3912982-3912476 [Morganella morganii subsp. morganii]
TTGAACTTAACGGCACCGGAACCCTTGCAGCAGCATCATGATTTTACCGTTTTTCAGTCAGGTGAGGAGTCCCTTAACCA
TTGGCTGAAAACCCGCGCATTGCAAAATCAGCAATCCGGCGCTTCACGGACATTTGTCGTCTGCCACCATAACCGGATAA
TGGCCTATTATGCATTATCGACAGGCGTTATTACCTGTTCACAGGCGGCGGGTCGTTTCAGACGTAATATGCCCCCGGAA
ATTCCGGTTATCCTGCCGGGACGTCTTGCTGTTGACGAAAGCGTAAAAGGCAGAGGGATCGGACGGGGTCTGATAAAAGA
TGCCGCACTGCGGGTCTTGCAGGCGGCCGGGATTGTGGGTATCCGCGGTATTGTTGTCCGTGCTCTGTCTGATAATGCCA
GACGTTTTTATGAGCATACCGGTTTTATGCCGTCACCGGCTGACCCGATGCTGCTGATGATTACATTACGGGATCTGCAG
CTGGCAACCGGCATCTATTCTGAATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10542.17 Da        Isoelectric Point: 6.9219

>AT149385 WP_045121630.1 NZ_CP048408:5755772-5756059 [Pseudomonas fluorescens]
MPMHNPPHPGETLLMDVLPELGISVTELARHLGFARPHLSRVLHGHAPISPDLAVRLERAGIGKARMWLGVQTDYDLWQA
EHREQPAIQPIAAHA

Download         Length: 288 bp

>AT149385 NZ_CP064055:c3913293-3912985 [Morganella morganii subsp. morganii]
ATGACAAAACACACAGATGAGCAGCATCCTGTGTCCGGCGTGAATATCACCCGTTCAACACTGAATTTACGCATCAAACC
GGAAGATAAAATTCTGATTGATCGCGCAGCGCATGCTGCCGGTAAAAACAGAACCGAGTTCGTACTGGAAGCTGCGCGGC
GTGCCGCCGAAGAAACACTGGCAGATTTACGGGTTATTGATGTCAGTACCGATGTCTATCAGCAGTTTATTACCAGACTG
GATATGGCACCACAGTCCGGTGAGGCGCTGAAGAAGACCATGCTGGCGAAGGCGCCGTGGGAGAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References