Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 726642..727336 | Replicon | chromosome |
Accession | NZ_CP048408 | ||
Organism | Pseudomonas fluorescens strain DR397 |
Toxin (Protein)
Gene name | higB | Uniprot ID | J2Q035 |
Locus tag | GZH78_RS03300 | Protein ID | WP_007952335.1 |
Coordinates | 726642..726938 (+) | Length | 99 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | A0A2N8H690 |
Locus tag | GZH78_RS03305 | Protein ID | WP_039766491.1 |
Coordinates | 726935..727336 (+) | Length | 134 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GZH78_RS03265 | 722307..722852 | - | 546 | WP_007952346.1 | hypothetical protein | - |
GZH78_RS03270 | 722849..723103 | - | 255 | WP_007947135.1 | acyl carrier protein | - |
GZH78_RS03275 | 723113..723373 | - | 261 | WP_085701087.1 | acyl carrier protein | - |
GZH78_RS03280 | 723354..724163 | - | 810 | WP_163973893.1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase | - |
GZH78_RS03285 | 724139..724864 | - | 726 | WP_064592952.1 | beta-ketoacyl synthase chain length factor | - |
GZH78_RS03290 | 725234..726004 | + | 771 | WP_007952339.1 | ParA family protein | - |
GZH78_RS03295 | 726012..726446 | - | 435 | WP_064592954.1 | thioredoxin TrxC | - |
GZH78_RS03300 | 726642..726938 | + | 297 | WP_007952335.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
GZH78_RS03305 | 726935..727336 | + | 402 | WP_039766491.1 | transcriptional regulator | Antitoxin |
GZH78_RS03310 | 727469..728932 | - | 1464 | WP_163973894.1 | YdiU family protein | - |
GZH78_RS03315 | 728981..732334 | - | 3354 | WP_039766495.1 | mechanosensitive channel MscK | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11297.14 Da Isoelectric Point: 10.6259
>T149381 WP_007952335.1 NZ_CP048408:726642-726938 [Pseudomonas fluorescens]
MHVITGKRIREAKAKWPNAATALDHWLEVAKGSKSPDFAALKALFPAVDKVGDFHVFDIGGNKLRLIAYVRYRPQKLYIR
HVLDHREYDRGKWKEAKA
MHVITGKRIREAKAKWPNAATALDHWLEVAKGSKSPDFAALKALFPAVDKVGDFHVFDIGGNKLRLIAYVRYRPQKLYIR
HVLDHREYDRGKWKEAKA
Download Length: 297 bp
>T149381 NZ_CP064054:c861701-861498 [Morganella morganii subsp. morganii]
ATGACTAAACTGGACTATCTCATGCGCTTACGTAAGTGCACTTCTATTGAAACACTGGAACGTGTCATTGAGAAAAACAA
ATATGAACTGACTGATGATGAGCTGGAGGTTTTTTATTCAGCAGCCGATCATCGTCTGGCCGAATTAACCATGAATAAAC
TGTATGACAAAATCCCGGCATCTGTCTGGAAATTTGTCCGTTAA
ATGACTAAACTGGACTATCTCATGCGCTTACGTAAGTGCACTTCTATTGAAACACTGGAACGTGTCATTGAGAAAAACAA
ATATGAACTGACTGATGATGAGCTGGAGGTTTTTTATTCAGCAGCCGATCATCGTCTGGCCGAATTAACCATGAATAAAC
TGTATGACAAAATCCCGGCATCTGTCTGGAAATTTGTCCGTTAA
Antitoxin
Download Length: 134 a.a. Molecular weight: 15294.51 Da Isoelectric Point: 4.8251
>AT149381 WP_039766491.1 NZ_CP048408:726935-727336 [Pseudomonas fluorescens]
MSVLIKKAAEHWEFVSPLLRKPKSEDDYDRLVQALDELLEMTGDDESHPLMSLVDIIGDWIEEWDRVHHPTPKPPGFEVL
GYLMREHGLTQSDLPGVGTQSVVSEILSGKRQLNLRQVRWLAEHFKLPVDVFI
MSVLIKKAAEHWEFVSPLLRKPKSEDDYDRLVQALDELLEMTGDDESHPLMSLVDIIGDWIEEWDRVHHPTPKPPGFEVL
GYLMREHGLTQSDLPGVGTQSVVSEILSGKRQLNLRQVRWLAEHFKLPVDVFI
Download Length: 402 bp
>AT149381 NZ_CP064054:c862124-861765 [Morganella morganii subsp. morganii]
ATGGACGAGTATTCTCCACGAAATTACGATATTGCGGTACTGAAGTATCTGTGTGATGAACTTTGCCGTGAAGGCACACA
AACCCTCATCAGAAGCAATAATTATTGGGTTAATGATTTAGCCTCAGATTCAAACTTAAAACTTAACGAATTATTAGGTT
ACATTGCTGACGTGGCCTGGAGTTTTAAGATAAAACATACACAAAATAAGGATCTCATCTCATTTGTCGATGAATACATC
GATGAAACTTACGCGCTGTTTGGTCAGATGGAAGTTTCGTTTAATGACGTTGAGGAATGGAAGAAGATGGCATCACTGGT
AAGCAGCATGCTGACCAGCGAGGGGCATCTTGTCCACTAA
ATGGACGAGTATTCTCCACGAAATTACGATATTGCGGTACTGAAGTATCTGTGTGATGAACTTTGCCGTGAAGGCACACA
AACCCTCATCAGAAGCAATAATTATTGGGTTAATGATTTAGCCTCAGATTCAAACTTAAAACTTAACGAATTATTAGGTT
ACATTGCTGACGTGGCCTGGAGTTTTAAGATAAAACATACACAAAATAAGGATCTCATCTCATTTGTCGATGAATACATC
GATGAAACTTACGCGCTGTTTGGTCAGATGGAAGTTTCGTTTAATGACGTTGAGGAATGGAAGAAGATGGCATCACTGGT
AAGCAGCATGCTGACCAGCGAGGGGCATCTTGTCCACTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | J2Q035 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2N8H690 |