Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 538855..539459 Replicon chromosome
Accession NZ_CP048408
Organism Pseudomonas fluorescens strain DR397

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GZH78_RS02395 Protein ID WP_163973850.1
Coordinates 539145..539459 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GZH78_RS02390 Protein ID WP_115076185.1
Coordinates 538855..539142 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZH78_RS02375 534697..536238 + 1542 WP_007952682.1 phosphoenolpyruvate carboxykinase -
GZH78_RS02380 536287..536928 - 642 WP_163973848.1 hypothetical protein -
GZH78_RS02385 536925..537797 - 873 WP_163973849.1 hypothetical protein -
GZH78_RS02390 538855..539142 - 288 WP_115076185.1 helix-turn-helix domain-containing protein Antitoxin
GZH78_RS02395 539145..539459 - 315 WP_163973850.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GZH78_RS02400 539571..539870 - 300 WP_115076187.1 hypothetical protein -
GZH78_RS02405 540421..541548 - 1128 WP_074689457.1 hypothetical protein -
GZH78_RS02410 541651..541932 - 282 WP_039764597.1 hypothetical protein -
GZH78_RS02415 542237..542740 + 504 WP_074689459.1 polysaccharide deacetylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(42-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-86)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11847.76 Da        Isoelectric Point: 10.3534

>T149379 WP_163973850.1 NZ_CP048408:c539459-539145 [Pseudomonas fluorescens]
MIFVETRIFTRRVKELLDDDTYAAFQKQLVVSPSIGDVIEGTGGIRKTRIAAKGHGKRGGARVIYYHFVSASQIGLLMIY
PKNEQHDLSSDERKALKLLIEKWR

Download         Length: 315 bp

>T149379 NZ_CP064051:48318-48668 [Enterococcus faecium]
ATGGTGAGAAAACCTAGACAAGGCGATATTCTATTATTGAATACAGCACCTCGATCTGGACACGAACAGACAGGTAAAAG
ACCTTATATTGTTTTAAGTCATGATATTATTGCGGATTATAGTAACGTTGTTACAGTTGCTCCAATTTCTAGTACAACTA
GAAACTATCCGCTATATGTAAATATAAACTCAGAATATGAAATGAAGACAACAGGAAAAGTATTATTAGATCAACTAACG
ACAATTGATTATGAAGCCAGAGAGTGTATTTTTTTGGAAAAAGCGCATGATAGTTTAGTTGAGGAGTTATTGATGAAAGT
TAGAACAGTTTTTCAAAAAGTAAGCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10713.31 Da        Isoelectric Point: 6.7193

>AT149379 WP_115076185.1 NZ_CP048408:c539142-538855 [Pseudomonas fluorescens]
MSKFFDELMESVQEMDEIVRGERTPSREFHVDALQVKEIRKATGLTQAKFAALIDVQLGTLRNWEQGRREPTGPAKALLK
AIHNDPVHVLNALAC

Download         Length: 288 bp

>AT149379 NZ_CP064051:48061-48324 [Enterococcus faecium]
ATGGAAATGTTACCTATAAAAAAATGGGGAAATAGTAATGGCCTTAGATTGCCAAAGTATATTATGGAATATCTTGGAAT
TCATACAGAAGACAAAGTGAAGATAATACAAGAAGAAGTAAACGGTCAGAAGCGGCTAATTATCGAAGCGGCTAATATAG
AAAATGAATTAACAATTGAACAGTTATTTGAAAATTACACTGATGAAAGAAATCATGTGACGATTCAAAATTTAGGTGAA
GCAGTAGGTAATGAAAAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References