Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 5639892..5640601 Replicon chromosome
Accession NZ_CP048405
Organism Streptacidiphilus sp. PB12-B1b

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag GXW83_RS24410 Protein ID WP_182447531.1
Coordinates 5640218..5640601 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GXW83_RS24405 Protein ID WP_182445207.1
Coordinates 5639892..5640221 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GXW83_RS24380 5635091..5635621 + 531 WP_182445201.1 thioredoxin -
GXW83_RS24385 5635621..5635884 + 264 WP_182445203.1 UBP-type zinc finger domain-containing protein -
GXW83_RS24390 5636023..5637651 + 1629 WP_182447530.1 FAD-dependent oxidoreductase -
GXW83_RS24395 5637688..5638137 + 450 WP_182445205.1 DUF1931 family protein -
GXW83_RS24400 5638250..5638744 - 495 Protein_4821 tetracycline resistance MFS efflux pump -
GXW83_RS24405 5639892..5640221 - 330 WP_182445207.1 helix-turn-helix domain-containing protein Antitoxin
GXW83_RS24410 5640218..5640601 - 384 WP_182447531.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GXW83_RS24415 5640975..5642270 - 1296 WP_182445156.1 IS256 family transposase -
GXW83_RS24420 5642295..5643920 - 1626 WP_182445209.1 hypothetical protein -
GXW83_RS24425 5643990..5645276 - 1287 WP_182445210.1 discoidin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(21-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-96)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14510.61 Da        Isoelectric Point: 5.0748

>T149376 WP_182447531.1 NZ_CP048405:c5640601-5640218 [Streptacidiphilus sp. PB12-B1b]
IVLLEPVELWFLGLCESEPETAVLVERALDRLSEVGPALGRPLVDTLAGSSLPKLKELRPGSRGRSELRLLFVFDPDREA
VFLVAGDKAGRWSRWYPEAMALAEQRYTAYRDEKKAERDQQVKEERR

Download         Length: 384 bp

>T149376 NZ_CP064049:438257-438598 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11761.37 Da        Isoelectric Point: 7.0745

>AT149376 WP_182445207.1 NZ_CP048405:c5640221-5639892 [Streptacidiphilus sp. PB12-B1b]
MSPARRWQDVKAEAHRRHPELADPQLRARADAQLDAQVAGFHLAELRKLVGKTQAEVAALVGVSQSRISQIEHGDIEAME
LETLRAYAAALGGHVDVTVSIGPHAVKVA

Download         Length: 330 bp

>AT149376 NZ_CP064049:438027-438257 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References