Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 4592993..4593501 Replicon chromosome
Accession NZ_CP048397
Organism Streptomyces sp. S4.7

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag SSPS47_RS20575 Protein ID WP_164252324.1
Coordinates 4592993..4593253 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag SSPS47_RS20580 Protein ID WP_078075549.1
Coordinates 4593250..4593501 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSPS47_RS20540 4588140..4588733 - 594 WP_164252316.1 hypothetical protein -
SSPS47_RS20545 4588743..4589534 + 792 WP_164254769.1 hypothetical protein -
SSPS47_RS20550 4589611..4590030 + 420 WP_164252317.1 hypothetical protein -
SSPS47_RS20555 4590262..4591170 - 909 WP_203557889.1 hypothetical protein -
SSPS47_RS20560 4591264..4591734 - 471 WP_164252319.1 ATP-binding protein -
SSPS47_RS20565 4591774..4592742 + 969 WP_164252320.1 helix-turn-helix domain-containing protein -
SSPS47_RS20570 4592739..4592948 + 210 WP_164252322.1 DUF397 domain-containing protein -
SSPS47_RS20575 4592993..4593253 - 261 WP_164252324.1 Txe/YoeB family addiction module toxin Toxin
SSPS47_RS20580 4593250..4593501 - 252 WP_078075549.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
SSPS47_RS20585 4593650..4593841 - 192 WP_147874346.1 DUF1059 domain-containing protein -
SSPS47_RS20590 4594352..4594660 + 309 WP_003948644.1 30S ribosomal protein S10 -
SSPS47_RS20595 4594675..4595319 + 645 WP_078075548.1 50S ribosomal protein L3 -
SSPS47_RS20600 4595324..4595986 + 663 WP_164252325.1 50S ribosomal protein L4 -
SSPS47_RS20605 4595986..4596303 + 318 WP_078075546.1 50S ribosomal protein L23 -
SSPS47_RS20610 4596351..4597187 + 837 WP_147874343.1 50S ribosomal protein L2 -
SSPS47_RS20615 4597200..4597481 + 282 WP_023539342.1 30S ribosomal protein S19 -
SSPS47_RS20620 4597525..4597872 + 348 WP_164252326.1 50S ribosomal protein L22 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10375.73 Da        Isoelectric Point: 8.8722

>T149368 WP_164252324.1 NZ_CP048397:c4593253-4592993 [Streptomyces sp. S4.7]
VKLVWSESAWDDYVWWQSEDRKVLKRINTLLQDVTRNGNEGIGKPEPLKHGFQGYWSRRITEEHRLVYKLVEDEVRIAAC
RYHYGR

Download         Length: 261 bp

>T149368 NZ_CP064046:1350434-1351756 [Klebsiella quasipneumoniae]
ATGGCGACGCTCACCACCTGGATGAACAATGCGCGCGTGGGAACCTTAACCCGCCAGGCCAACGGGGCGCACAGTTTCCG
CTATGATGAGGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCGCTGCCGCTGCAGTATGGCAATATTACCG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGAGCGGATCGTCAGGCGCTATCAG
GCGCGTTCGAAACAGCCGTTCGATCTGCTGGCCGAGGTCGGGCGGGACAGCGTAGGGGCGGTGACTCTGCTGCCGCCGGG
GGAAGAGGCGCATCTTGCCGCGTTGCGCTGGCAGACGCTGGATGAGGCGCAGCTGACCGCTTTGCTGACCGCCTACCAGT
CGGATATTCCTCTCGGAATGGTGACCGGCCAGGACGATTTTCGTATCTCGGTGGCCGGCGCTCAGGAGAAAACCGCGCTG
CTGCGAATGGGCGAGCACTGGTGTATTCCGCAGGGCACCACCCCGACCACCCATATCATTAAACTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAACGAATATCTGTGCCTGGCGCTGGCCAGGGCGTTGG
GCCTGGCGGTGCCGGAGGCGGAGATTATCAACACGCCGCGGATCCGTGCGCTGGCGGTGACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGGCGCGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCATTCGGCATACCGTCGTCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCCAGTGAGGCCCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTGTTCCAGTGGCTGACCGGGGCAACGGACGGGCATGCGAAGAACTTCTCGCTCTTTTTGCTG
CCCGGCGGCAGCTACCGGCTCACGCCGTTCTACGACATTATTTCGGCATTTCCGGTGCTGGGCGGGACGGGACTGCATCT
GCGCGACCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGGAAAACGGAGATTAACGCTATCTATCCGCGTCATT
TTCTGGCGACCGCCAAAGCGGTTAACTTCCCCCGGGAGCAGATGCTGGCGATCCTGGGCGAGTTTGCCGACCGCGTGCCG
CAGGCCATCGAAAGCGCCCGCCAAACGCTGCCGTCGGACTTTTCCGCCCACGTCTGGCGGGCCATCACGGAGAACATGCT
GAAACTGCACGCCCGCCTGCAGCAAGGGCTGCTGGCGGGATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9304.36 Da        Isoelectric Point: 4.2696

>AT149368 WP_078075549.1 NZ_CP048397:c4593501-4593250 [Streptomyces sp. S4.7]
MRTMSYTESRAKYAETLDSVVNDREEVIITRAGHDAVVMVALDDYESLKETAYLLRNPENARRLLASIDQLENGGGTVQE
LAE

Download         Length: 252 bp

>AT149368 NZ_CP064046:1350168-1350434 [Klebsiella quasipneumoniae]
ATGAATTCCCCGCAGATATACAGTCCGGTTCAGCTGGCCAATTACCTGAAACTGCTGCGCCAGCAAAATCACTGGACTCA
GGAGGCGCTGGCCAGCCGGATCGGCATTAAACAGGCGACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACCCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACCCTGAACGCCAAACCGGCAGAGACGGCGATGATTCCC
GATAACACCACGGATCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References