149305

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 1209667..1210333 Replicon chromosome
Accession NZ_CP048382
Organism Citrobacter freundii strain 62

Toxin (Protein)


Gene name higB Uniprot ID A0A8B5Q945
Locus tag GZS04_RS05875 Protein ID WP_003847996.1
Coordinates 1209667..1209984 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A4U6IRD5
Locus tag GZS04_RS05880 Protein ID WP_003837894.1
Coordinates 1210037..1210333 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZS04_RS05860 1204842..1205720 + 879 WP_003023531.1 Hsp33 family molecular chaperone HslO -
GZS04_RS05865 1205825..1207543 - 1719 WP_046671282.1 DUF4153 domain-containing protein -
GZS04_RS05870 1207922..1209544 + 1623 WP_003023529.1 phosphoenolpyruvate carboxykinase (ATP) -
GZS04_RS05875 1209667..1209984 + 318 WP_003847996.1 hypothetical protein Toxin
GZS04_RS05880 1210037..1210333 + 297 WP_003837894.1 helix-turn-helix domain-containing protein Antitoxin
GZS04_RS05885 1210390..1211742 - 1353 WP_003837891.1 two-component system sensor histidine kinase EnvZ -
GZS04_RS05890 1211739..1212458 - 720 WP_001157751.1 two-component system response regulator OmpR -
GZS04_RS05895 1212684..1213157 + 474 WP_003023524.1 transcription elongation factor GreB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(39-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12225.15 Da        Isoelectric Point: 10.0909

>T149305 WP_003847996.1 NZ_CP048382:1209667-1209984 [Citrobacter freundii]
MFTFIELQGFSKRRPLLLPDDEFRAFQEALIENPEAGDTIAGTGGFRKIRWSRSGMGKRSGIRVIYYNVTRKGRIYLALL
YPKNEQDDLTEEQKRVLMHLSNMLI

Download         Length: 318 bp

>T149305 NZ_CP063993:2666257-2666391 [Xanthomonas translucens pv. undulosa]
ATGAAGCGTACTTTCGCGTGGATGCTGCTGGCGATGTTCTCGGTGGGCCTGCTGTCGGGCTGCAACACGGTTGCCGGTGC
CGGCAAGGACGTGAAGAGCGCCGGCGAGAAGGTCGAAGACGCCGCCAAGAACTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11157.93 Da        Isoelectric Point: 7.2050

>AT149305 WP_003837894.1 NZ_CP048382:1210037-1210333 [Citrobacter freundii]
MKDELFADLLASAEEMVRIEKGEETPKPEHVHTFSEIDVKAIREATGLRQQDFAIAVGVSYDLVKSWETKRRQPTGAPRK
LLLLIQKNPFIINQLKAI

Download         Length: 297 bp

>AT149305 NZ_CP063993:2666006-2666158 [Xanthomonas translucens pv. undulosa]
ATGAAGCGACTGTTCACCTTGACGATGCTGACCCTGTTTTGTGCAGGCATGCTGACCGGCTGCAACACCATGGCCGGCGC
CGGTAAGGACATGCAGAAGGCCGGCGATAAGGTGGAAACCAAGGCCGACGACTGTAAAGACGGCAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B5Q945

Antitoxin

Source ID Structure
AlphaFold DB A0A4U6IRD5

References