Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1934884..1935386 Replicon chromosome
Accession NZ_CP048337
Organism Escherichia coli strain 142

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag GZS12_RS09015 Protein ID WP_000767829.1
Coordinates 1935132..1935386 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag GZS12_RS09010 Protein ID WP_001259255.1
Coordinates 1934884..1935135 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZS12_RS08985 1930062..1931129 - 1068 WP_001563933.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
GZS12_RS08990 1931129..1932199 - 1071 WP_000108970.1 histidinol-phosphate transaminase -
GZS12_RS08995 1932196..1933500 - 1305 WP_001559366.1 histidinol dehydrogenase -
GZS12_RS09000 1933506..1934405 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
GZS12_RS09005 1934551..1934601 - 51 WP_001364200.1 his operon leader peptide -
GZS12_RS09010 1934884..1935135 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
GZS12_RS09015 1935132..1935386 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
GZS12_RS09020 1935469..1936293 + 825 WP_000754749.1 SDR family oxidoreductase -
GZS12_RS09025 1936339..1937268 + 930 WP_000803351.1 LysR family transcriptional regulator -
GZS12_RS09030 1937483..1937545 + 63 WP_010723108.1 membrane protein YoeI -
GZS12_RS09035 1937535..1938893 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
GZS12_RS09040 1939072..1940130 + 1059 WP_023910197.1 transport protein YeeE -
GZS12_RS09045 1940144..1940371 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T149108 WP_000767829.1 NZ_CP048337:1935132-1935386 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T149108 NZ_CP063929:c99015-98866 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT149108 WP_001259255.1 NZ_CP048337:1934884-1935135 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT149108 NZ_CP063929:99060-99119 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References