148959

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 194854..195456 Replicon chromosome
Accession NZ_CP048304
Organism Escherichia coli strain 9

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag GZS17_RS00880 Protein ID WP_000897302.1
Coordinates 195145..195456 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GZS17_RS00875 Protein ID WP_000356397.1
Coordinates 194854..195144 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZS17_RS00850 190928..191830 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
GZS17_RS00855 191827..192462 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
GZS17_RS00860 192459..193388 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
GZS17_RS00865 193603..193821 - 219 WP_001314326.1 ribbon-helix-helix domain-containing protein -
GZS17_RS00870 194217..194495 - 279 WP_001296612.1 hypothetical protein -
GZS17_RS00875 194854..195144 - 291 WP_000356397.1 helix-turn-helix domain-containing protein Antitoxin
GZS17_RS00880 195145..195456 - 312 WP_000897302.1 hypothetical protein Toxin
GZS17_RS00885 195686..196594 + 909 WP_001305059.1 alpha/beta hydrolase -
GZS17_RS00890 196658..197599 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
GZS17_RS00895 197644..198081 - 438 WP_000560983.1 D-tyrosyl-tRNA(Tyr) deacylase -
GZS17_RS00900 198078..198950 - 873 WP_000920762.1 virulence factor BrkB family protein -
GZS17_RS00905 198944..199543 - 600 WP_001443191.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T148959 WP_000897302.1 NZ_CP048304:c195456-195145 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

>T148959 NZ_CP063910:c1420142-1420040 [Klebsiella variicola]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT148959 WP_000356397.1 NZ_CP048304:c195144-194854 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp

>AT148959 NZ_CP063910:1420034-1420178 [Klebsiella variicola]
ACCGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGT
TGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References