148920

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 65940..66743 Replicon plasmid pB61a
Accession NZ_CP048244
Organism Ewingella americana strain B6-1

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag GXP68_RS21670 Protein ID WP_185690456.1
Coordinates 66291..66743 (+) Length 151 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID -
Locus tag GXP68_RS21665 Protein ID WP_185690455.1
Coordinates 65940..66278 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GXP68_RS21650 62765..63718 + 954 WP_185690452.1 bifunctional helix-turn-helix transcriptional regulator/GNAT family N-acetyltransferase -
GXP68_RS21655 63696..64310 - 615 WP_185690453.1 TetR/AcrR family transcriptional regulator -
GXP68_RS21660 64370..65566 - 1197 WP_185690454.1 MFS transporter -
GXP68_RS21665 65940..66278 + 339 WP_185690455.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
GXP68_RS21670 66291..66743 + 453 WP_185690456.1 type II toxin-antitoxin system YhaV family toxin Toxin
GXP68_RS21675 66835..67965 + 1131 WP_185690457.1 FAD-dependent monooxygenase -
GXP68_RS21680 68011..68732 + 722 Protein_70 GntR family transcriptional regulator -
GXP68_RS21685 68719..69159 - 441 WP_185690458.1 GNAT family N-acetyltransferase -
GXP68_RS21690 69503..69724 + 222 Protein_72 hypothetical protein -
GXP68_RS21695 70107..71393 + 1287 WP_185690459.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..331410 331410


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(11-146)

Antitoxin

PrlF antitoxin

(14-112)


Sequences

Toxin        


Download         Length: 151 a.a.        Molecular weight: 17332.93 Da        Isoelectric Point: 9.6415

>T148920 WP_185690456.1 NZ_CP048244:66291-66743 [Ewingella americana]
VESLEINGWKIYFHGCFTEQLLKLRQEVNALKASNPHDYLNKRPTKLLAAIMQVIERVASDPLGAQFRLGNTLGPANKHW
FRAKFLQQYRLFFRCSDKHKTIVIAWVNDEKTKRAYDSKTDAYKVFESMLNAGEPPDDWDALLCAATKTR

Download         Length: 453 bp

>T148920 NZ_CP063904:c1384196-1382874 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTACCGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCGGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACTCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12391.02 Da        Isoelectric Point: 4.3384

>AT148920 WP_185690455.1 NZ_CP048244:65940-66278 [Ewingella americana]
MVTLKMADVSLRAESRLTERSQTTIPASIRDALNLKPGEHIEYSLLPGGQVILSKKDDNQDDPVVAQFLAFLENDMTQNP
QHIHAVPKALWSDIKELTAGVEIDLDAPLTDE

Download         Length: 339 bp

>AT148920 NZ_CP063904:c1384462-1384196 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGATGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References