Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 142505..143232 | Replicon | chromosome |
Accession | NZ_CP048243 | ||
Organism | Ewingella americana strain B6-1 |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A377N786 |
Locus tag | GXP68_RS00655 | Protein ID | WP_034793981.1 |
Coordinates | 142921..143232 (-) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | GXP68_RS00650 | Protein ID | WP_185689023.1 |
Coordinates | 142505..142924 (-) | Length | 140 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GXP68_RS00630 | 138140..138775 | - | 636 | WP_034793993.1 | carbonic anhydrase | - |
GXP68_RS00635 | 139086..139631 | + | 546 | WP_034793991.1 | peptide-methionine (S)-S-oxide reductase MsrA | - |
GXP68_RS00640 | 139833..141098 | + | 1266 | WP_185689022.1 | bifunctional tetrahydrofolate synthase/dihydrofolate synthase | - |
GXP68_RS00645 | 141172..141897 | - | 726 | WP_202034344.1 | tetrahydrodipicolinate succinyltransferase | - |
GXP68_RS00650 | 142505..142924 | - | 420 | WP_185689023.1 | helix-turn-helix domain-containing protein | Antitoxin |
GXP68_RS00655 | 142921..143232 | - | 312 | WP_034793981.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
GXP68_RS00660 | 143432..143881 | - | 450 | WP_185689024.1 | GyrI-like domain-containing protein | - |
GXP68_RS00665 | 144156..145508 | - | 1353 | WP_185689025.1 | glutathione-disulfide reductase | - |
GXP68_RS00670 | 145702..146544 | - | 843 | WP_154145719.1 | 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ | - |
GXP68_RS00675 | 146730..147320 | - | 591 | WP_185690100.1 | histidine phosphatase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12173.84 Da Isoelectric Point: 9.3110
>T148903 WP_034793981.1 NZ_CP048243:c143232-142921 [Ewingella americana]
MHVVSKGPFDEAAQKFPNDAKALNDVYRAFKRGNFSDPDEMREVFPSLDRMKYRDKWWVVDVGGNNLRLMFFADFEYGRL
FIKSISTHAEYDKLVKKYRENPA
MHVVSKGPFDEAAQKFPNDAKALNDVYRAFKRGNFSDPDEMREVFPSLDRMKYRDKWWVVDVGGNNLRLMFFADFEYGRL
FIKSISTHAEYDKLVKKYRENPA
Download Length: 312 bp
>T148903 NZ_CP063900:c1292261-1292159 [Klebsiella quasipneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 140 a.a. Molecular weight: 15464.68 Da Isoelectric Point: 4.4057
>AT148903 WP_185689023.1 NZ_CP048243:c142924-142505 [Ewingella americana]
MISEAIKASQQLVSIVPLLGGSTSKADYKEAVKLAEYLVEFDPSNPLIEMLTAKIDRYENESPDFAEFNALLAATPPGIS
MLRVLMDQYGLTQSDFENEIGQRSLVSRILNGDRNLTVEHMKALAKRFNLPVSIFVNED
MISEAIKASQQLVSIVPLLGGSTSKADYKEAVKLAEYLVEFDPSNPLIEMLTAKIDRYENESPDFAEFNALLAATPPGIS
MLRVLMDQYGLTQSDFENEIGQRSLVSRILNGDRNLTVEHMKALAKRFNLPVSIFVNED
Download Length: 420 bp
>AT148903 NZ_CP063900:1292155-1292302 [Klebsiella quasipneumoniae]
AGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTG
GCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGTCTGCG
AGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTG
GCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGTCTGCG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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