Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3036136..3036719 Replicon chromosome
Accession NZ_CP048114
Organism Edaphobacter sp. 12200R-103

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag GWR55_RS12595 Protein ID WP_162402578.1
Coordinates 3036136..3036417 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GWR55_RS12600 Protein ID WP_162402579.1
Coordinates 3036432..3036719 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWR55_RS12580 3031225..3031602 + 378 WP_162402575.1 PadR family transcriptional regulator -
GWR55_RS12585 3031599..3034283 + 2685 WP_162402576.1 ABC transporter permease -
GWR55_RS12590 3034324..3035955 + 1632 WP_162402577.1 hypothetical protein -
GWR55_RS12595 3036136..3036417 + 282 WP_162402578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GWR55_RS12600 3036432..3036719 + 288 WP_162402579.1 HigA family addiction module antidote protein Antitoxin
GWR55_RS12605 3036789..3037667 - 879 WP_162402580.1 pirin family protein -
GWR55_RS12610 3037673..3038167 - 495 WP_162402581.1 MarR family winged helix-turn-helix transcriptional regulator -
GWR55_RS12615 3038388..3039320 + 933 WP_162402582.1 hypothetical protein -
GWR55_RS12620 3039625..3040605 + 981 WP_162402583.1 zinc-dependent alcohol dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-66)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10712.12 Da        Isoelectric Point: 8.9846

>T148894 WP_162402578.1 NZ_CP048114:3036136-3036417 [Edaphobacter sp. 12200R-103]
VITGFSDADTEELWETGKNRRLPANLRRSAWKKLAILHAALELANLRVPPGNRLEALTGDRKGQHSIRINDQYHICFRWK
SGNAYEVEIVDYH

Download         Length: 282 bp

>T148894 NZ_CP063898:3080324-3081646 [Klebsiella variicola]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGCACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCGCTGCCGCTGCAGTATGGCAATATCACCG
CCGACGCGGTGTATCACTATTTTGATAATCTGCTGCCCGACAGCCCGCAGGTCCGCGATCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTGGGACGGGATAGCGTAGGGGCGGTGACTCTGCTACCGCCGGG
GGAAGAGGCGCACCTCGAGGGGTTGCGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCCTACCAGT
CGGATATCCCTCTCGGGATGATTACCGGCCAGGATGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGGGCACTGGTGTATTCCGCAGGGCACCACGCCGACCACGCATATCATTAAACTGCCCATCGGCGAGAT
AAAGCAGCCTAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAACGAGTTTCTGTGCCTGGCGCTGGCCAGGGAACTGG
GCCTGGCGGTGCCGGAGGCAGAGATTATCACCACGCCGCGGATCCGCGCGCTGGCGGTGACCCGCTTTGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCCTTTGGCATCCCGTCGTCGATGAAATA
TGAATCTGACGGCGGGCCGGGTATTGCGGCAATCATGGCCTTTCTGCTGGGCTCCAGTGAAGCCCTGAAAGATCGCGCAG
ACTTTATGAAATTCATGGTTTTTCAGTGGCTGGTTGGGGCAACGGACGGGCATGCGAAGAACTTCTCGCTCTTTTTGCTG
CCCGGTGGCAGCTACCGTCTAACGCCGTTCTACGACATCATTTCGGCGTTTCCGGTGCTGGGAGGTACGGGACTGCATCT
GCGCGACCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGGAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCAACCGCCAAAGCGGTGAACTTTCCTGGGGAGCTGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCACCCACGTCTGGCGGGCCATTACGGAAAATATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGTTATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10741.58 Da        Isoelectric Point: 10.4529

>AT148894 WP_162402579.1 NZ_CP048114:3036432-3036719 [Edaphobacter sp. 12200R-103]
MPKNFAIHPGEILRTEFLEPLGLSVYRLAQAIEVPLPRINDVVKGKRSISADTALRLGIYFGLPAQFWLNLQNEYDLRHA
RTPALKKIKPHPQAA

Download         Length: 288 bp

>AT148894 NZ_CP063898:3080058-3080324 [Klebsiella variicola]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTATCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACACTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTAGGGGTGGTGATGACGCTGAACGCCAAAGCCACAGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References