Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2916218..2916864 Replicon chromosome
Accession NZ_CP048114
Organism Edaphobacter sp. 12200R-103

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GWR55_RS12130 Protein ID WP_162402496.1
Coordinates 2916218..2916508 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GWR55_RS12135 Protein ID WP_162402497.1
Coordinates 2916556..2916864 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWR55_RS12115 2912990..2913454 - 465 WP_162402493.1 hypothetical protein -
GWR55_RS12120 2913456..2914403 - 948 WP_162402494.1 hypothetical protein -
GWR55_RS12125 2914842..2915231 - 390 WP_162402495.1 hypothetical protein -
GWR55_RS12130 2916218..2916508 + 291 WP_162402496.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GWR55_RS12135 2916556..2916864 + 309 WP_162402497.1 HigA family addiction module antidote protein Antitoxin
GWR55_RS12140 2917046..2917252 + 207 WP_162402498.1 hypothetical protein -
GWR55_RS12145 2917455..2919266 + 1812 WP_162402499.1 glycoside hydrolase family 127 protein -
GWR55_RS12150 2919434..2920123 - 690 WP_162402500.1 Ig-like domain-containing protein -
GWR55_RS12155 2920116..2920454 - 339 WP_162402501.1 PadR family transcriptional regulator -
GWR55_RS12160 2920740..2921741 - 1002 WP_162402502.1 Gfo/Idh/MocA family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-95)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11582.11 Da        Isoelectric Point: 7.4694

>T148893 WP_162402496.1 NZ_CP048114:2916218-2916508 [Edaphobacter sp. 12200R-103]
MIESWRDRWLQEFFEQDVRPKKIPADLADRLFRKLQMLDDATTDADLRVPPSNHFEKLKGTLTGFHSIRVNGHWRLVFHW
ERGKATEVYLDDHSYR

Download         Length: 291 bp

>T148893 NZ_CP063898:1699908-1700225 [Klebsiella variicola]
ATATTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAAATAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCATCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11724.62 Da        Isoelectric Point: 10.4665

>AT148893 WP_162402497.1 NZ_CP048114:2916556-2916864 [Edaphobacter sp. 12200R-103]
MSITKRKPVSVGEILVEEFLEPLGITQTELAERTGLPRKHVNELCRNRRAITADTALILARVFGNSADFWLNTQRRMDIW
EAINTPDRLKRIERAKPLEKVA

Download         Length: 309 bp

>AT148893 NZ_CP063898:1700218-1700505 [Klebsiella variicola]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTAGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTGACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGTGGAATAAAGCACCCACAAATTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References