Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 2849580..2849805 Replicon chromosome
Accession NZ_CP048107
Organism Escherichia coli strain 201609

Toxin (Protein)


Gene name hokW Uniprot ID -
Locus tag GWK05_RS13750 Protein ID WP_197731663.1
Coordinates 2849580..2849735 (-) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 2849747..2849805 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWK05_RS13710 2845286..2845471 - 186 WP_001228696.1 prophage lysis lipoprotein RzoD -
GWK05_RS13715 2845688..2846185 - 498 WP_001135296.1 lysozyme RrrD -
GWK05_RS13720 2846185..2846400 - 216 WP_001587000.1 phage lysis protein EssD -
GWK05_RS13735 2847688..2848230 - 543 WP_000640136.1 DUF1133 family protein -
GWK05_RS13740 2848227..2848517 - 291 WP_001586999.1 DUF1364 domain-containing protein -
GWK05_RS13745 2848517..2849116 - 600 WP_000940324.1 DUF1367 family protein -
GWK05_RS13750 2849580..2849735 - 156 WP_197731663.1 type I toxin-antitoxin system Hok family toxin Toxin
- 2849747..2849805 + 59 - - Antitoxin
GWK05_RS13755 2850065..2851123 + 1059 WP_001586997.1 nucleoid-associated protein -
GWK05_RS13760 2851095..2852528 + 1434 WP_001586996.1 hypothetical protein -
GWK05_RS13765 2852559..2853077 - 519 WP_001586995.1 hypothetical protein -
GWK05_RS13770 2853238..2853660 - 423 WP_001586994.1 DUF977 family protein -
GWK05_RS13775 2853677..2854402 - 726 WP_000450652.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2817324..2864960 47636


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5752.93 Da        Isoelectric Point: 6.1389

>T148859 WP_197731663.1 NZ_CP048107:c2849735-2849580 [Escherichia coli]
MKQQKAMLVALIVICLTVIVTVLVTRKDLCEVRIRTDQTEVAVFTAYELGE

Download         Length: 156 bp

>T148859 NZ_CP063887:4344425-4344527 [Klebsiella quasipneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 59 bp

>AT148859 NZ_CP048107:2849747-2849805 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References