Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 2604662..2604887 Replicon chromosome
Accession NZ_CP048107
Organism Escherichia coli strain 201609

Toxin (Protein)


Gene name hokW Uniprot ID S1ELB5
Locus tag GWK05_RS12585 Protein ID WP_000813254.1
Coordinates 2604732..2604887 (+) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 2604662..2604720 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWK05_RS12570 2599919..2600320 + 402 WP_001151189.1 DUF977 family protein -
GWK05_RS12580 2602028..2603482 + 1455 WP_032341362.1 hypothetical protein -
- 2604662..2604720 - 59 - - Antitoxin
GWK05_RS12585 2604732..2604887 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD Toxin
GWK05_RS12590 2605104..2605355 + 252 WP_000980999.1 hypothetical protein -
GWK05_RS12595 2605422..2605700 + 279 WP_032140164.1 hypothetical protein -
GWK05_RS12600 2605702..2606751 + 1050 WP_096940148.1 DUF968 domain-containing protein -
GWK05_RS12605 2606764..2607120 + 357 WP_000904111.1 RusA family crossover junction endodeoxyribonuclease -
GWK05_RS12610 2607135..2607956 + 822 WP_096940147.1 antitermination protein -
GWK05_RS12625 2608897..2608983 + 87 WP_000114359.1 DUF3927 family protein -
GWK05_RS12630 2609350..2609778 + 429 WP_000506936.1 cell envelope integrity protein TolA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2579987..2648023 68036


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5736.89 Da        Isoelectric Point: 6.1531

>T148856 WP_000813254.1 NZ_CP048107:2604732-2604887 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Download         Length: 156 bp

>T148856 NZ_CP063887:1142696-1142914 [Klebsiella quasipneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAACAAATATGAACTTTCTGATAATGAGCTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACTATGAATAAGCTGTACGATAAAATCCCGACGTCCGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 59 bp

>AT148856 NZ_CP048107:c2604720-2604662 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATATGTCTAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TMW0

Antitoxin

Download structure file

References