Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2971939..2972587 Replicon chromosome
Accession NZ_CP048071
Organism Mycobacterium tuberculosis strain RW-TB008

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID A0A7U8TVG5
Locus tag tig002_RS13975 Protein ID WP_003909715.1
Coordinates 2971939..2972262 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag tig002_RS13980 Protein ID WP_003899415.1
Coordinates 2972342..2972587 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
tig002_RS13945 2967262..2968260 + 999 WP_003908027.1 tyrosine-type recombinase/integrase -
tig002_RS13950 2968274..2968738 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
tig002_RS13955 2968726..2968977 + 252 WP_003908028.1 hypothetical protein -
tig002_RS13960 2969148..2970587 - 1440 WP_003901443.1 phage major capsid protein -
tig002_RS13965 2970595..2971128 - 534 WP_003899412.1 HK97 family phage prohead protease -
tig002_RS13970 2971281..2971772 - 492 WP_003900541.1 phage terminase small subunit P27 family -
tig002_RS13975 2971939..2972262 - 324 WP_003909715.1 type II toxin-antitoxin system toxin Toxin
tig002_RS13980 2972342..2972587 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
tig002_RS13985 2972584..2974011 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
tig002_RS13990 2974013..2974405 - 393 WP_003899417.1 DUF2742 domain-containing protein -
tig002_RS13995 2974402..2974662 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
tig002_RS14000 2974679..2975041 - 363 WP_003900543.1 hypothetical protein -
tig002_RS14005 2975044..2976171 - 1128 WP_031705441.1 site-specific integrase -
tig002_RS14010 2976316..2976542 - 227 Protein_2746 hypothetical protein -
tig002_RS14015 2976539..2976928 - 390 WP_003899422.1 hypothetical protein -
tig002_RS14020 2976834..2977106 + 273 WP_003900544.1 hypothetical protein -
tig002_RS14025 2977205..2977438 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2967262..2976171 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12350.81 Da        Isoelectric Point: 8.6568

>T148824 WP_003909715.1 NZ_CP048071:c2972262-2971939 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYQFPDEPDSKQ

Download         Length: 324 bp

>T148824 NZ_CP063881:c981868-981551 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT148824 WP_003899415.1 NZ_CP048071:c2972587-2972342 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT148824 NZ_CP063881:c981558-981271 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8TVG5

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References