Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Gp49-HTH_37 |
| Location | 2193378..2194246 | Replicon | chromosome |
| Accession | NZ_CP048071 | ||
| Organism | Mycobacterium tuberculosis strain RW-TB008 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | P9WJA4 |
| Locus tag | tig002_RS10200 | Protein ID | WP_010886136.1 |
| Coordinates | 2193378..2193755 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | G0TLM0 |
| Locus tag | tig002_RS10205 | Protein ID | WP_003409886.1 |
| Coordinates | 2193797..2194246 (+) | Length | 150 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| tig002_RS10150 | 2189167..2189619 | - | 453 | WP_003899095.1 | lipoprotein | - |
| tig002_RS10155 | 2189683..2190084 | + | 402 | WP_003409869.1 | hypothetical protein | - |
| tig002_RS10160 | 2190077..2190259 | - | 183 | WP_003409870.1 | hypothetical protein | - |
| tig002_RS10165 | 2190373..2190723 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| tig002_RS10170 | 2190734..2191636 | - | 903 | WP_031705400.1 | hypothetical protein | - |
| tig002_RS10175 | 2191657..2191848 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| tig002_RS10180 | 2191849..2192145 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| tig002_RS10185 | 2192385..2192600 | + | 216 | WP_003409878.1 | antitoxin | - |
| tig002_RS10190 | 2192597..2192908 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| tig002_RS10195 | 2192882..2193403 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| tig002_RS10200 | 2193378..2193755 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | Toxin |
| tig002_RS10205 | 2193797..2194246 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
| tig002_RS10210 | 2194243..2194788 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| tig002_RS10215 | 2194677..2195291 | - | 615 | Protein_2003 | hypothetical protein | - |
| tig002_RS10220 | 2195340..2195636 | - | 297 | WP_031705402.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| tig002_RS10225 | 2195633..2195884 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| tig002_RS10230 | 2195871..2196365 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| tig002_RS10235 | 2196525..2196932 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| tig002_RS10240 | 2196936..2197208 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| tig002_RS10245 | 2197241..2198461 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14397.77 Da Isoelectric Point: 10.8862
>T148808 WP_010886136.1 NZ_CP048071:2193378-2193755 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
Download Length: 378 bp
>T148808 NZ_CP063877:49368-49793 [Klebsiella quasipneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGTGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAAGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCT
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACCGCCATTGC
CGGACACGCCATCGCGGCGGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGAGCGGGTGCCGGGTCTGGTTCTGG
AAGACTGGGTTGGCTTTGTTGAATAA
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGTGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAAGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCT
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACCGCCATTGC
CGGACACGCCATCGCGGCGGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGAGCGGGTGCCGGGTCTGGTTCTGG
AAGACTGGGTTGGCTTTGTTGAATAA
Antitoxin
Download Length: 150 a.a. Molecular weight: 16760.16 Da Isoelectric Point: 8.0771
>AT148808 WP_003409886.1 NZ_CP048071:2193797-2194246 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
Download Length: 450 bp
>AT148808 NZ_CP063877:49141-49371 [Klebsiella quasipneumoniae]
ATGCGCACAGTATCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGACGAAGGACGCTTTGATCCATGA
ATGCGCACAGTATCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGACGAAGGACGCTTTGATCCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|