Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 34510..35046 Replicon plasmid Ps8079A-p1
Accession NZ_CP048067
Organism Piscirickettsia salmonis strain Ps-8079A

Toxin (Protein)


Gene name yoeB Uniprot ID A0A6I5YBD1
Locus tag GW535_RS16795 Protein ID WP_016211910.1
Coordinates 34510..34782 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B8U9U2
Locus tag GW535_RS16800 Protein ID WP_032126795.1
Coordinates 34786..35046 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GW535_RS16770 29697..30071 - 375 WP_016212499.1 hypothetical protein -
GW535_RS16775 30408..31010 - 603 Protein_49 IS30 family transposase -
GW535_RS16780 31070..32223 + 1154 WP_129556499.1 IS3 family transposase -
GW535_RS16785 32232..32630 - 399 WP_075273786.1 helix-turn-helix domain-containing protein -
GW535_RS16790 33063..34184 + 1122 WP_016211913.1 hypothetical protein -
GW535_RS16795 34510..34782 - 273 WP_016211910.1 Txe/YoeB family addiction module toxin Toxin
GW535_RS16800 34786..35046 - 261 WP_032126795.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GW535_RS16805 35319..35909 + 591 WP_016211912.1 site-specific integrase -
GW535_RS16810 35999..36700 + 702 WP_129556698.1 IS6 family transposase -
GW535_RS16815 36814..37179 + 366 WP_054300249.1 IS630 transposase-related protein -
GW535_RS16820 37194..37700 + 507 WP_129556449.1 IS630 family transposase -
GW535_RS16830 38936..39412 - 477 WP_051307374.1 Clp protease ClpP -
GW535_RS16835 39653..39979 + 327 WP_016212298.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..200877 200877
- flank IS/Tn - - 35999..36700 701


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-74)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10739.22 Da        Isoelectric Point: 7.8926

>T148771 WP_016211910.1 NZ_CP048067:c34782-34510 [Piscirickettsia salmonis]
MSKLNLLTWSDDAWDDYLYWQDTDKKVLKKINKLIKECQRTPTEGIGHPEPLKHDFSGYWSRKIKGEHRLVYSFDATSLM
IAACRYHYDQ

Download         Length: 273 bp

>T148771 NZ_CP063867:c3849508-3849125 [Klebsiella variicola]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGTACGCGAATGGCGCTAAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAACGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTGATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAACTACACCCTGAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9555.93 Da        Isoelectric Point: 5.1167

>AT148771 WP_032126795.1 NZ_CP048067:c35046-34786 [Piscirickettsia salmonis]
MLRDNINATAARDNFKSTCDTVCENNAPVLVKRKGAEDVVIISASDFGGMEETIHLLSSRIMATRLMRSMKQLDEGKGVQ
RDIIEE

Download         Length: 261 bp

>AT148771 NZ_CP063867:c3849750-3849508 [Klebsiella variicola]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGATGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I5YBD1

Antitoxin

Source ID Structure
AlphaFold DB A0A0B8U9U2

References