Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 159705..160241 Replicon plasmid Ps11091B-p1
Accession NZ_CP048053
Organism Piscirickettsia salmonis strain Ps-11091B

Toxin (Protein)


Gene name yoeB Uniprot ID A0A1L6THY5
Locus tag GW538_RS17315 Protein ID WP_036772441.1
Coordinates 159969..160241 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B8U9U2
Locus tag GW538_RS17310 Protein ID WP_032126795.1
Coordinates 159705..159965 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GW538_RS17275 155371..156348 - 978 WP_036771347.1 IS5 family transposase -
GW538_RS17280 156423..157073 + 651 WP_155046631.1 hypothetical protein -
GW538_RS17285 157157..157363 + 207 Protein_202 IS6 family transposase -
GW538_RS17290 157414..157581 - 168 Protein_203 IS6 family transposase -
GW538_RS17295 157651..158283 + 633 Protein_204 IS6-like element ISPsa2 family transposase -
GW538_RS17300 158349..158915 - 567 Protein_205 IS6 family transposase -
GW538_RS17305 159201..159365 - 165 Protein_206 IS6 family transposase -
GW538_RS17310 159705..159965 + 261 WP_032126795.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GW538_RS17315 159969..160241 + 273 WP_036772441.1 Txe/YoeB family addiction module toxin Toxin
GW538_RS17320 160317..161045 + 729 WP_017375910.1 IS6 family transposase -
GW538_RS17325 161614..162678 - 1065 WP_174872554.1 IS91 family transposase -
GW538_RS17330 162858..163037 - 180 WP_157894752.1 hypothetical protein -
GW538_RS17335 163450..164277 + 828 WP_048876208.1 IS30 family transposase -
GW538_RS17340 164320..165049 - 730 Protein_213 IS6 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..203283 203283
- inside IScluster/Tn - - 139477..170663 31186


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-74)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10785.31 Da        Isoelectric Point: 7.8926

>T148762 WP_036772441.1 NZ_CP048053:159969-160241 [Piscirickettsia salmonis]
MSKLNLLTWSDDAWDDYLYWQDTDKKVLKKINKLIKECQRMPTEGIGHPEPLKHDFSGYWSRKIKGEHRLVYSFDATSLM
ISACRYHYDQ

Download         Length: 273 bp

>T148762 NZ_CP063866:c24803-24321 [Klebsiella pneumoniae]
GTGGGATGTATAACTGCGCCCGAGCCGTTATCCAGCGCCCATCAACTGGCAGAGTTCGTCAGTGGGGAAACGGTACTCGA
TGAATGGTTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCACGAACTTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTTTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTTCACGATGCGGTTCTACGCTGTTATCGCGTAGCTGAGAATATTGGCGTTCGTGCGATAATGGTTCACGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCGCAAACTTATGAGCGGACTCTGTTCCTTAAACTTCCA
TGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9555.93 Da        Isoelectric Point: 5.1167

>AT148762 WP_032126795.1 NZ_CP048053:159705-159965 [Piscirickettsia salmonis]
MLRDNINATAARDNFKSTCDTVCENNAPVLVKRKGAEDVVIISASDFGGMEETIHLLSSRIMATRLMRSMKQLDEGKGVQ
RDIIEE

Download         Length: 261 bp

>AT148762 NZ_CP063866:c25057-24791 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGGGCACTCATCGATGCCGCTGCAGAAATCCTTCA
TAAATCGCGAACCGACTTCATTCTTGAGATGGCCTGCAAGGCTGCGGAGAACGTGATCCTTGATCGTCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCTGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L6THY5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B8U9U2

References