Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 248105..248695 Replicon chromosome
Accession NZ_CP048039
Organism Alcaligenes faecalis strain MUB14

Toxin (Protein)


Gene name higB Uniprot ID A0A0A2N9E1
Locus tag GWQ43_RS01125 Protein ID WP_035268575.1
Coordinates 248399..248695 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag GWQ43_RS01120 Protein ID WP_042484646.1
Coordinates 248105..248392 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWQ43_RS01105 243892..245139 + 1248 WP_162089636.1 D-amino acid dehydrogenase -
GWQ43_RS01110 245338..246348 - 1011 WP_162089637.1 acyltransferase family protein -
GWQ43_RS01115 246627..247994 + 1368 WP_162089638.1 DNA recombination protein RmuC -
GWQ43_RS01120 248105..248392 - 288 WP_042484646.1 HigA family addiction module antidote protein Antitoxin
GWQ43_RS01125 248399..248695 - 297 WP_035268575.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GWQ43_RS01130 248829..251393 - 2565 WP_162091047.1 EAL domain-containing protein -
GWQ43_RS01135 251571..251849 + 279 WP_045930570.1 acylphosphatase -
GWQ43_RS01140 252006..252902 + 897 WP_162089639.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-98)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-64)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11108.48 Da        Isoelectric Point: 9.3459

>T148746 WP_035268575.1 NZ_CP048039:c248695-248399 [Alcaligenes faecalis]
MIKSFRHKGLQAYFETGSKSGIQAKHAVRLQIQLTALHSATQAEDMNAPGWKLHKLSGKNPKGQSVQDHYTISVSGNWRL
TFYFEGEDAVLVDYQDYH

Download         Length: 297 bp

>T148746 NZ_CP063863:3478631-3478733 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10430.96 Da        Isoelectric Point: 9.8929

>AT148746 WP_042484646.1 NZ_CP048039:c248392-248105 [Alcaligenes faecalis]
IMRMHNPSHPGPVLREYLGELSVTEAASRLGVTRAALSRILNGSAGISADMALRLRDALGTSAEMWINMQSHYDLWQAEQ
KPRPKVVSFHGPAHA

Download         Length: 288 bp

>AT148746 NZ_CP063863:c3478740-3478595 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A2N9E1

Antitoxin

Source ID Structure

References