Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 677184..677817 Replicon chromosome
Accession NZ_CP048030
Organism Sinimarinibacterium sp. NLF-5-8

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GT972_RS03415 Protein ID WP_162077337.1
Coordinates 677184..677510 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GT972_RS03420 Protein ID WP_162077338.1
Coordinates 677503..677817 (+) Length 105 a.a.

Genomic Context

GT972_RS03390GT972_RS03395GT972_RS03400GT972_RS03405GT972_RS03415GT972_RS03420GT972_RS03425GT972_RS03430GT972_RS03385GT972_RS03410GT972_RS03435GT972_RS03440GT972_RS03445GT972_RS03450
Location: 673660..674247 (588 bp)
Type: Others
Protein ID: WP_162077334.1
Location: 674354..674794 (441 bp)
Type: Others
Protein ID: WP_199222834.1
Location: 674876..675229 (354 bp)
Type: Others
Protein ID: WP_202922547.1
Location: 675313..676539 (1227 bp)
Type: Others
Protein ID: WP_162077336.1
Location: 677184..677510 (327 bp)
Type: Toxin
Protein ID: WP_162077337.1
Location: 677503..677817 (315 bp)
Type: Antitoxin
Protein ID: WP_162077338.1
Location: 677950..678192 (243 bp)
Type: Others
Protein ID: WP_162077339.1
Location: 678189..678452 (264 bp)
Type: Others
Protein ID: WP_162077340.1
Location: 673209..673493 (285 bp)
Type: Others
Protein ID: WP_202922546.1
Location: 676577..677056 (480 bp)
Type: Others
Protein ID: Protein_670
Location: 678508..678718 (211 bp)
Type: Others
Protein ID: Protein_675
Location: 678803..679333 (531 bp)
Type: Others
Protein ID: WP_162077341.1
Location: 679466..680233 (768 bp)
Type: Others
Protein ID: WP_162077342.1
Location: 680252..682309 (2058 bp)
Type: Others
Protein ID: WP_162077343.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GT972_RS03385673209..673493-285WP_202922546.1phage integrase N-terminal SAM-like domain-containing protein-
GT972_RS03390673660..674247+588WP_162077334.1NAD(P)H-dependent oxidoreductase-
GT972_RS03395674354..674794+441WP_199222834.1hypothetical protein-
GT972_RS03400674876..675229+354WP_202922547.1DUF1304 domain-containing protein-
GT972_RS03405675313..676539+1227WP_162077336.1IS256 family transposase-
GT972_RS03410676577..677056-480Protein_670transposase-
GT972_RS03415677184..677510+327WP_162077337.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GT972_RS03420677503..677817+315WP_162077338.1helix-turn-helix domain-containing proteinAntitoxin
GT972_RS03425677950..678192+243WP_162077339.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GT972_RS03430678189..678452+264WP_162077340.1Txe/YoeB family addiction module toxin-
GT972_RS03435678508..678718-211Protein_675type II toxin-antitoxin system YoeB family toxin-
GT972_RS03440678803..679333-531WP_162077341.1DUF2726 domain-containing protein-
GT972_RS03445679466..680233-768WP_162077342.1exodeoxyribonuclease III-
GT972_RS03450680252..682309-2058WP_162077343.1M3 family metallopeptidase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegron--673660..6785134853


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(41-96)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12437.51 Da        Isoelectric Point: 10.2637

>T148741 WP_162077337.1 NZ_CP048030:677184-677510 [Sinimarinibacterium sp. NLF-5-8]
MAYRIEYFHARVLAEIESWPVDVLADYARLAELLTEHGPNLRLPHSRAFGDGLFELRPRGRSGIGRALYCFLLGKRIVVV
HAFIKKTQETPDKDLKLARKRVKELQHG

Download         Length: 327 bp

>T148741 NZ_CP063863:c1469075-1468692 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCATCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11416.21 Da        Isoelectric Point: 10.3191

>AT148741 WP_162077338.1 NZ_CP048030:677503-677817 [Sinimarinibacterium sp. NLF-5-8]
MANLTYKPVVHDHQVFLARASKRKGFAEAYEALELEYQLAGQMLKARSKAGLTQDAVAERMGTTKSAISRLESASKKHAP
SIATLQRYAQAVGCDLQVKLVPQK

Download         Length: 315 bp

>AT148741 NZ_CP063863:c1469317-1469075 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
No matching records found

References