Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 805973..806559 Replicon chromosome
Accession NZ_CP048014
Organism Acinetobacter towneri strain 205

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GVU25_RS03815 Protein ID WP_096900967.1
Coordinates 806251..806559 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag GVU25_RS03810 Protein ID WP_167845867.1
Coordinates 805973..806254 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVU25_RS03785 800997..802175 - 1179 WP_096900969.1 FAD-dependent oxidoreductase -
GVU25_RS03790 802248..802412 - 165 WP_004972007.1 rubredoxin -
GVU25_RS03795 802897..803439 + 543 WP_004972003.1 adenine phosphoribosyltransferase -
GVU25_RS03800 803550..804056 - 507 WP_026438299.1 alpha/beta fold hydrolase -
GVU25_RS03805 804373..805899 + 1527 WP_096900968.1 lysine--tRNA ligase -
GVU25_RS03810 805973..806254 - 282 WP_167845867.1 HigA family addiction module antidote protein Antitoxin
GVU25_RS03815 806251..806559 - 309 WP_096900967.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GVU25_RS03820 806686..807216 - 531 WP_096900966.1 hypothetical protein -
GVU25_RS03825 807571..808479 + 909 WP_026438300.1 sulfate adenylyltransferase subunit CysD -
GVU25_RS03830 808624..810240 + 1617 WP_096900965.1 sulfate adenylyltransferase subunit CysN -
GVU25_RS03835 810325..810792 - 468 WP_167845868.1 GNAT family N-acetyltransferase -
GVU25_RS03840 811074..811550 + 477 WP_167845869.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11454.04 Da        Isoelectric Point: 10.2252

>T148689 WP_096900967.1 NZ_CP048014:c806559-806251 [Acinetobacter towneri]
MIKSFKHKGLQAFFQTGSTAGIQAAHSTKLRLILAALHAASTVNDLRTPPNWRLHKLSGNLQDQWSLTVNGNWRVIFKFE
DGDVYIVDYLDYHIASSAGVQR

Download         Length: 309 bp

>T148689 NZ_CP063845:4445416-4445844 [Gloeobacter morelensis MG652769]
ATGACCTACCTTCTAGATGTGAATGTGTTGCTTTCTTTGAGCGATCCGATGCACGTACACCATGAAGCGGCTCACCGCTG
GTTTGCCGCCCGGGGGCGATCCGCCTGGGCAACCTGTCCCATCACCGAAAACGGCTTTATCCGCATTGCCAGCCATCCCG
GTTATCCGAACCGGCCAGGAGATGTACCTGTGGTGATGGGTATCTTGCGTCAGTTTTGCGCGGCCCAGGGTCATCACTTT
TGGGGCGCAAATGTCAGCCTTCTTTCGATGCTGCACACCGGTATAGTCCTTACACACTCTCAGATTACAGATATTTTTCT
GCTTGGCCTGGCCGCTCACCAAGGCGGCAAACTGGCCACCTTCGACAGGCGAATTGCTGTCGATACGGTTCACGGTGGCA
ATGAAGCGTTGGAACTGATTGCTCCTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10481.08 Da        Isoelectric Point: 6.2142

>AT148689 WP_167845867.1 NZ_CP048014:c806254-805973 [Acinetobacter towneri]
MNMMFNAPHPGEMLREYIGETSVTEEAQALGVTRANLSRILNGHTGISADMAIRLSEALETSPEFWLNLQMQHDLWLASQ
RQRPMIKKLVASV

Download         Length: 282 bp

>AT148689 NZ_CP063845:4445189-4445416 [Gloeobacter morelensis MG652769]
ATGCGGACGACCCTCGATCTTGAAGAAGATGTGCTGCTTGCAGCCAAGGAAATTGCTCGGCAGCGGGGAGTTTCCCTTGG
GAAAGTTTTTTCGGATCTGGCACGGCAGGCATTGTCGGGTTCCTCGGATGTATCGATCCGTAATGGTGTACCGCTCTTTC
CCGTGCACGATCAATCCGGCATTGCCACGCTGGAACTGATCAACCGGCTGCGCGACGAAGTGCCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References