Detailed information of TA system TA148530

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2647968..2648246
• Replicon: chromosome
• Accession: NZ_CP047924
• Organism: Staphylococcus aureus strain SR130

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: GWG03_RS13035
• Protein ID: WP_001802298.1
• Coordinates: 2647968..2648072 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2648068..2648246 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GWG03_RS13015	2644765..2645547	+	783	WP_000908182.1	ABC transporter ATP-binding protein	-
GWG03_RS13020	2645615..2646472	+	858	WP_000370925.1	Cof-type HAD-IIB family hydrolase	-
GWG03_RS13025	2647130..2647288	-	159	WP_001792784.1	hypothetical protein	-
GWG03_RS13030	2647281..2647451	-	171	WP_001792292.1	transposase	-
GWG03_RS13035	2647968..2648072	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2648068..2648246	-	179	-	-	Antitoxin
GWG03_RS13040	2648505..2649596	-	1092	WP_000495669.1	hypothetical protein	-
GWG03_RS13045	2649862..2650839	-	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
GWG03_RS13050	2650841..2651161	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
GWG03_RS13055	2651313..2651978	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T148530 WP_001802298.1 NZ_CP047924:2647968-2648072 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T148530 NZ_CP063773:c1467425-1467138 [Pectobacterium carotovorum subsp. carotovorum PCCS1]
ATGAGCTATAGCGTCAAATTCAGGGAAGATGCGCTGAAAGAATGGCTCAAGCTCGATAAAACCATCCAGCAGCAATTTGC
CAAAAAACTAAAAAAATGCTGCGAAAATCCCCATATTCCTTCGGCAAAATTACGGGGGATGAAGGACTGCTACAAAATAA
AGCTCCGAGCATCAGGCTTTCGTTTGGTTTATGAAGTCATTGACGATGTATTGATTATCGCCGTAGTGGCGGTAGGTAAA
CGTGAACGCAGTGGCGTTTATCATCTGGCGAGTGAGCGAATGAGATAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT148530 NZ_CP047924:c2648246-2648068 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin