Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2387700..2388217 | Replicon | chromosome |
| Accession | NZ_CP047924 | ||
| Organism | Staphylococcus aureus strain SR130 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A3A3ATA4 |
| Locus tag | GWG03_RS11680 | Protein ID | WP_000113265.1 |
| Coordinates | 2387951..2388217 (+) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | GWG03_RS11675 | Protein ID | WP_000584499.1 |
| Coordinates | 2387700..2387951 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GWG03_RS11645 (2383397) | 2383397..2384116 | + | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
| GWG03_RS11650 (2384113) | 2384113..2384844 | + | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| GWG03_RS11655 (2384941) | 2384941..2386192 | - | 1252 | Protein_2275 | FemA/FemB family glycyltransferase FmhA | - |
| GWG03_RS11660 (2386447) | 2386447..2386809 | + | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| GWG03_RS11665 (2386828) | 2386828..2387427 | + | 600 | WP_000162810.1 | DsbA family protein | - |
| GWG03_RS11670 (2387455) | 2387455..2387535 | + | 81 | WP_223197974.1 | hypothetical protein | - |
| GWG03_RS11675 (2387700) | 2387700..2387951 | + | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| GWG03_RS11680 (2387951) | 2387951..2388217 | + | 267 | WP_000113265.1 | Txe/YoeB family addiction module toxin | Toxin |
| GWG03_RS11685 (2388252) | 2388252..2388323 | + | 72 | Protein_2281 | hypothetical protein | - |
| GWG03_RS11690 (2388512) | 2388512..2390059 | + | 1548 | WP_000727756.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| GWG03_RS11695 (2390245) | 2390245..2390712 | + | 468 | WP_000153347.1 | SRPBCC domain-containing protein | - |
| GWG03_RS11700 (2390796) | 2390796..2390978 | + | 183 | WP_000230292.1 | hypothetical protein | - |
| GWG03_RS11705 (2391195) | 2391195..2392019 | + | 825 | WP_000572038.1 | formate/nitrite transporter family protein | - |
| GWG03_RS11710 (2392253) | 2392253..2392789 | + | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10436.96 Da Isoelectric Point: 10.0573
>T148528 WP_000113265.1 NZ_CP047924:2387951-2388217 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T148528 NZ_CP063773:c1163041-1162766 [Pectobacterium carotovorum subsp. carotovorum PCCS1]
ATGCAGGGAAAAATAGCCAGTCTACGAAAAAAGCAGCGAGAAACGCTGAGCCAAATTTTCAAAACACCCGTGCTTTCAGG
TGTTAAATGGTCAAATGTTGAGTCACTCATCACTGCGTTAGGTGGTGAAATTAAGGAAGGTAGCGGGTCACGGGTGCGAT
TTTTATTGAATGGGAGTATCGCCCGGTTCCATCGTCCTCACCCGTCACCGGATACTGATAAAGGCGCATTGGTTAACCTG
CGTGAATGGTTGGAAAGTATAGGAGTAAAACTATGA
ATGCAGGGAAAAATAGCCAGTCTACGAAAAAAGCAGCGAGAAACGCTGAGCCAAATTTTCAAAACACCCGTGCTTTCAGG
TGTTAAATGGTCAAATGTTGAGTCACTCATCACTGCGTTAGGTGGTGAAATTAAGGAAGGTAGCGGGTCACGGGTGCGAT
TTTTATTGAATGGGAGTATCGCCCGGTTCCATCGTCCTCACCCGTCACCGGATACTGATAAAGGCGCATTGGTTAACCTG
CGTGAATGGTTGGAAAGTATAGGAGTAAAACTATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT148528 WP_000584499.1 NZ_CP047924:2387700-2387951 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT148528 NZ_CP063773:c1162769-1162407 [Pectobacterium carotovorum subsp. carotovorum PCCS1]
ATGACTAAAGCACTTAACACACCAAATACGATGGTTGTTTCCGGCCAACCGGCCATTATCAGCTATGTACCGGAAATCGG
TATGTTTCGCGGTAAGTTTATTGGCTTATCTGGCTACTGTGATTTTGTCGCTGACAGTATTAATGGGCTGAGAAACGAGG
GCGAAATTTCGCTACGTGAATATCTGGAAGACTGTCAGGAAAATGGCATTGAACCTTACGAACGTGAAGAGAAGGTGAAA
ACGTTCACTCTCCGTTATCCTGAATCATTCGGAGAACGACTGACTATTGCGGCGGCTGAACGTCAAATTTCAGTGAATAC
GTTTATTGTCGAAACGCTTAATGAACGTATGAAACAGGCTTAA
ATGACTAAAGCACTTAACACACCAAATACGATGGTTGTTTCCGGCCAACCGGCCATTATCAGCTATGTACCGGAAATCGG
TATGTTTCGCGGTAAGTTTATTGGCTTATCTGGCTACTGTGATTTTGTCGCTGACAGTATTAATGGGCTGAGAAACGAGG
GCGAAATTTCGCTACGTGAATATCTGGAAGACTGTCAGGAAAATGGCATTGAACCTTACGAACGTGAAGAGAAGGTGAAA
ACGTTCACTCTCCGTTATCCTGAATCATTCGGAGAACGACTGACTATTGCGGCGGCTGAACGTCAAATTTCAGTGAATAC
GTTTATTGTCGAAACGCTTAATGAACGTATGAAACAGGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|