Detailed information of TA system TA148526

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2362660..2362844
• Replicon: chromosome
• Accession: NZ_CP047924
• Organism: Staphylococcus aureus strain SR130

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: GWG03_RS11545
• Protein ID: WP_000482652.1
• Coordinates: 2362660..2362767 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2362784..2362844 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GWG03_RS11520	2358022..2358495	+	474	WP_000456486.1	GyrI-like domain-containing protein	-
GWG03_RS11525	2358618..2359829	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
GWG03_RS11530	2360011..2360670	-	660	WP_000831298.1	membrane protein	-
GWG03_RS11535	2360730..2361872	-	1143	WP_001176863.1	glycerate kinase	-
GWG03_RS11540	2362140..2362526	+	387	WP_000779360.1	flippase GtxA	-
GWG03_RS11545	2362660..2362767	+	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2362784..2362844	-	61	-	-	Antitoxin
GWG03_RS11550	2363470..2365233	+	1764	WP_001064825.1	ABC transporter ATP-binding protein	-
GWG03_RS11555	2365258..2366991	+	1734	WP_000486487.1	ABC transporter ATP-binding protein	-
GWG03_RS11560	2367258..2367389	+	132	WP_223197975.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T148526 WP_000482652.1 NZ_CP047924:2362660-2362767 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T148526 NZ_CP063772:2210134-2210448 [Lysobacter sp. H21R4]
ATGATCTTCATCGAGACCGCGGTGTTCACCCGCCAAATCAGCGAGATGGTGACGGACGAGCGATACGCCGAGTTCCAGCG
CCTCCTGGCCGACAGCCCTGAAGCGGGAGATGTCATCAAGGGCACGGGCGGCCTTCGGAAGATCCGTCTCGCGCTGGACA
ATCGCGGCAAGAGCGGCGGCTCCCGAGTCATCTACTACTACTTCGTGAACGCCTCGCAAATCGCCCTGTTATTCGCCTAT
CCGAAGAACGTAGCCAGCGACCTGACCGCCGAGCAAAAGGCCGTACTGAAACAAATCATCGCGAAGTGGAGTTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT148526 NZ_CP047924:c2362844-2362784 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin